E-64d
E-64d structure
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Common Name | E-64d | ||
|---|---|---|---|---|
| CAS Number | 88321-09-9 | Molecular Weight | 342.431 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 470.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H30N2O5 | Melting Point | 126.2°C | |
| MSDS | USA | Flash Point | 238.4±31.5 °C | |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
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Polymorphisms in Ion Transport Genes Are Associated with Eggshell Mechanical Property.
PLoS ONE 10 , e0130160, (2015) Eggshell mechanical property traits such as eggshell breaking strength (ESS), eggshell thickness (EST) and eggshell weight (ESW) are most common and important indexes to evaluate eggshell quality in poultry industry. Uterine ion transporters involve in eggshe... |
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Preferential expression of a bromoperoxidase in sporophytes of a red alga, Pyropia yezoensis.
Mar. Biotechnol. 17(2) , 199-210, (2015) A 2,158 bp cDNA (PyBPO1) encoding a bromoperoxidase (BPO) of 625 amino acids was isolated from Pyropia yezoensis. Phylogenetic analysis using amino acid sequences of BPOs suggested that P. yezoensis and cyanobacteria were grouped in the same clade and separat... |
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Comparative proteomic and biochemical analyses reveal different molecular events occurring in the process of fiber initiation between wild-type allotetraploid cotton and its fuzzless-lintless mutant.
PLoS ONE 10(2) , e0117049, (2015) To explore lint fiber initiation-related proteins in allotetraploid cotton (Gossypium hirsutum L.), a comparative proteomic analysis was performed between wild-type cotton (Xu-142) and its fuzzless-lintless mutant (Xu-142-fl) at five developmental time points... |
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Heterologous expression of newly identified galectin-8 from sea urchin embryos produces recombinant protein with lactose binding specificity and anti-adhesive activity.
Sci. Rep. 5 , 17665, (2015) Galectin family members specifically bind beta-galactoside derivatives and are involved in different cellular events, including cell communication, signalling, apoptosis, and immune responses. Here, we report a tandem-repeat type galectin from the Paracentrot... |
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Potassium transporter TRH1 subunits assemble regulating root-hair elongation autonomously from the cell fate determination pathway.
Plant Sci. 231 , 131-7, (2015) Trichoblasts of trh1 plants form root-hair initiation sites that fail to undergo tip growth resulting in a tiny root-hair phenotype. TRH1 belongs to Arabidopsis KT/KUP/HAK potassium transporter family controlling root-hair growth and gravitropism. Double muta... |
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Transpapillary drug delivery to the breast.
PLoS ONE 9(12) , e115712, (2014) The study was aimed at investigating localized topical drug delivery to the breast via mammary papilla (nipple). 5-fluorouracil (5-FU) and estradiol (EST) were used as model hydrophilic and hydrophobic compounds respectively. Porcine and human nipple were use... |
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Distinct Metal Isoforms Underlie Promiscuous Activity Profiles of Metalloenzymes.
ACS Chem. Biol. 10 , 1684-93, (2015) Within a superfamily, functionally diverged metalloenzymes often favor different metals as cofactors for catalysis. One hypothesis is that incorporation of alternative metals expands the catalytic repertoire of metalloenzymes and provides evolutionary springb... |
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Superoxide dismutases, SOD1 and SOD2, play a distinct role in the fat body during pupation in silkworm Bombyx mori.
PLoS ONE 10(2) , e0116007, (2015) One way that aerobic biological systems counteract the generation of reactive oxygen species (ROS) is with superoxide dismutase proteins SOD1 and SOD2 that metabolize superoxide radicals to molecular oxygen and hydrogen peroxide or scavenge oxygen radicals pr... |
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Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.
J. Biol. Chem. 290 , 14077-90, (2015) Ribonucleotide reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair. In mammals, the R1 catalytic subunit forms an active complex with either one of the two small subunits R2 and p53R2. Expression of R2 is S phase-s... |