EM20-25
EM20-25 structure
|
Common Name | EM20-25 | ||
|---|---|---|---|---|
| CAS Number | 141266-44-6 | Molecular Weight | 376.70800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H9ClN4O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.
PLoS ONE 5(3) , e9924, (2010) Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apoptotic machinery to induce tumor cell death. In this study, we... |
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The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.
J. Biol. Chem. 281 , 10066-10072, (2006) We have investigated the mitochondrial effects of BH3I-2', Chelerythrine, and HA14-1, small organic molecules that share the ability to bind the BH3 domain of BCL-2. All compounds displayed a biphasic effect on mitochondrial respiration with uncoupling at low... |
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