GSK343
GSK343 structure
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Common Name | GSK343 | ||
|---|---|---|---|---|
| CAS Number | 1346704-33-3 | Molecular Weight | 541.687 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 797.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C31H39N7O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 436.0±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues.
Nucleic Acids Res. 43 , 6814-26, (2015) Ten-eleven translocation (Tet) genes encode for a family of hydroxymethylase enzymes involved in regulating DNA methylation dynamics. Tet1 is highly expressed in mouse embryonic stem cells (ESCs) where it plays a critical role the pluripotency maintenance. Te... |
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DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.
Oncogene 34 , 5869-78, (2015) Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy and genetic instability. This study profiles DNA methylation in SCLC, patient-derived xenografts (PDX) and cell lines ... |
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H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells.
J. Virol. 89(16) , 8392-405, (2015) Histone methyltransferase inhibitors (HMTis) and histone deacetylase inhibitors (HDACis) are reported to synergistically induce the expression of latent human immunodeficiency virus type 1 (HIV-1), but studies have largely been performed with cell lines. As s... |
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Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer.
Oncotarget 7 , 3440-52, (2016) Androgen deprivation therapy is the mainstay of treatment of advanced prostate cancer (PCa). However, a significant portion of patients experience disease relapse and tumors ultimately evolve into castration resistant prostate cancer (CRPC), for which there i... |
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DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study.
Oncotarget 6(2) , 915-34, (2015) Radioresistance is still an emerging problem for radiotherapy of oral cancer. Aberrant epigenetic alterations play an important role in cancer development, yet the role of such alterations in radioresistance of oral cancer is not fully explored. Using a methy... |