PR-619
PR-619 structure
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Common Name | PR-619 | ||
|---|---|---|---|---|
| CAS Number | 2645-32-1 | Molecular Weight | 223.278 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 406.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C7H5N5S2 | Melting Point | 210℃ | |
| MSDS | Chinese USA | Flash Point | 199.3±28.7 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials.
Malaria Journal 14 , 200, (2015) The ubiquitin proteasome system (UPS) is one of the main proteolytical pathways in eukaryotic cells and plays an essential role in key cellular processes such as cell cycle, stress response, signal transduction, and transcriptional regulation. Many components... |
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Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages.
Antonie van Leeuwenhoek 108 , 163-71, (2015) Mycobacterium bovis is the causative agent of tuberculosis in cattle. Infection of macrophages with M. bovis leads to the activation of the "nucleotide binding and oligomerization, leucine-rich repeat and pyrin domains-containing protein 3" (NLRP3) and "absen... |
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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry.
Nat. Commun. 5 , 4763, (2014) Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and ... |
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Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction.
J. Biol. Chem. 291 , 939-47, (2016) Intracellular trafficking of viruses can be influenced by a variety of inter-connected cellular sorting and degradation pathways involving endo-lysosomal vesicles, the ubiquitin-proteasome system, and autophagy-based or endoplasmic reticulum-associated machin... |
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Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.
Biochim. Biophys. Acta 1863 , 50-5, (2015) The NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen ... |