TDZD-8
TDZD-8 structure
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Common Name | TDZD-8 | ||
|---|---|---|---|---|
| CAS Number | 327036-89-5 | Molecular Weight | 222.264 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 335.5±35.0 °C at 760 mmHg | |
| Molecular Formula | C10H10N2O2S | Melting Point | 63-64.4ºC | |
| MSDS | Chinese USA | Flash Point | 156.7±25.9 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation.
Biochem. J. 468 , 177-90, (2015) The serotonin [5-HT (5-hydroxytryptamine)] transporter (SERT) controls serotonergic neurotransmission in the brain by rapid clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary targets for antidepressants for therapeutic inter... |
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Learning ability is a key outcome determinant of GSK-3 inhibition on visuospatial memory in rats.
J. Psychopharmacol. 29 , 822-35, (2015) Learning aptitude has never been a focus of visuospatial performance studies, particularly on memory consolidation and reconsolidation. The aim of this study was to determine the consequences of learning ability on memory consolidation/reconsolidation followi... |
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Glycogen synthase kinase 3 regulates IL-1β mediated iNOS expression in hepatocytes by down-regulating c-Jun.
J. Cell. Biochem. 116(1) , 133-41, (2014) Excessive nitric oxide from the inducible nitric oxide synthase (iNOS) increases shock-induced hepatic injury, hepatic dysfunction, inflammation, and mortality in animal models. Cytokines increase the expression of iNOS in hepatocytes, but the signaling mecha... |
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S-Adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancer.
Mol. Pharmacol. 87(1) , 77-86, (2015) S-Adenosylmethionine (SAMe), the principal methyl donor that is available as a nutritional supplement, and its metabolite methylthioadenosine (MTA) exert chemopreventive properties against liver and colon cancer in experimental models. Both agents reduced β-c... |
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GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
Cancer Cell 17(6) , 597-608, (2010) Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcript... |
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Roles of GSK3β in odor habituation and spontaneous neural activity of the mouse olfactory bulb.
PLoS ONE 8(5) , e63598, (2013) Glycogen synthase kinase 3β (GSK3β), a multifaceted kinase, is abundantly expressed in the brain, including the olfactory bulb (OB). In resting cells, GSK3β is constitutively active, and its over-activation is presumably involved in numerous brain diseases, s... |