Atipamezole
Atipamezole structure
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Common Name | Atipamezole | ||
|---|---|---|---|---|
| CAS Number | 104054-27-5 | Molecular Weight | 212.290 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 367.1±11.0 °C at 760 mmHg | |
| Molecular Formula | C14H16N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 178.0±5.7 °C | |
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Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.
Neurobiol. Aging 36 , 2414-28, (2015) There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-in... |
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Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation.
Int. J. Pharm. 483(1-2) , 6-18, (2015) A challenge exists to produce dry powder inhaler (DPI) formulations with appropriate formulation stability, biological activity and suitable physicochemical and aerosolisation characteristics that provide a viable alternative to parenteral formulations. The p... |
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Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease.
Mol. Ther. 23(2) , 244-54, (2015) Cerebral Dopamine Neurotrophic Factor (CDNF) and Mesencephalic Astrocyte-derived Neurotrophic factor (MANF) are members of a recently discovered family of neurotrophic factors (NTFs). Here, we used intranigral or intrastriatal lentiviral vector-mediated expre... |
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Behavioral effects of phencyclidine on nicotine self-administration and reinstatement in the presence or absence of a visual stimulus in rats.
Psychopharmacology 232 , 2877-87, (2015) Tobacco use is a serious health problem in the USA, and this problem is potentiated in patients with schizophrenia. The reward system is implicated in schizophrenia and may contribute to the high comorbidity between nicotine use and schizophrenia, but very li... |
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Bovine Tuberculosis and Brucellosis in Cattle and African Buffalo in the Limpopo National Park, Mozambique.
Transbound. Emerg. Dis. 62 , 632-8, (2015) Bovine tuberculosis (BTB) and brucellosis are prevalent in buffaloes of the Kruger National Park (KNP, South Africa). Both diseases were considered to have no or a very low prevalence in wildlife and livestock in and around the Limpopo National Park (LNP, Moz... |
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Effect of an extruded pea or rice diet on postprandial insulin and cardiovascular responses in dogs.
J. Anim. Physiol. Anim. Nutr. (Berl.) 99 , 767-76, (2015) Peas are increasing in popularity as a source of carbohydrate, protein and fibre in extruded canine diets. The aim of this study was to test the health effects of two canine diets with identical macronutrient profiles, but containing either yellow field peas ... |
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The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response.
Cell. Transplant. 25 , 55-69, (2016) Therapeutic effects of skeletal myoblast transplantation into the myocardium are mediated via paracrine factors. We investigated the ability of myoblast-derived soluble mediators to protect cardiomyocytes from oxidative stress. Fetal rat cardiac cells were tr... |
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Hyperventilation in normoxia following myocardial infarction in rats: a shift in the set point of the hypoxic ventilatory response.
Acta Physiol. (Oxf.) 214 , 415-25, (2015) The peripheral chemoreflex is augmented in heart failure, and it may contribute to sympathoexcitation. This study aimed to investigate both the chemoreflex and the cardiac sympathetic nerve activity in the acute-stage post-myocardial infarction.Myocardial inf... |
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Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors.
Behav. Brain Res. 282 , 14-24, (2015) Amygdala is involved in processing of primary emotions and particularly its central nucleus (CeA) also in pain control. Here we studied mechanisms mediating the descending control of mechanical hypersensitivity by the CeA in rats with a peripheral neuropathy ... |
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Comparison of two injectable immobilization combinations in Himalayan tahr (Hemitragus jemlahicus): medetomidine, ketamine, and atipamezole versus carfentanil, xylazine, naltrexone, and atipamezole.
J. Zoo Wildl. Med. 44(3) , 596-604, (2013) A crossover study was performed in 12 Himalayan tahr (Hemitragus jemlahicus) undergoing preshipment examinations to compare a partially reversible to a fully reversible intramuscular chemical immobilization protocol. The partially reversible protocol (MKA) co... |