DC Chemicals Limited
China
Product Name: Atipamezole
Price: $350.0/100mg $700.0/250mg $1400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Atipamezole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

104054-27-5

104054-27-5 structure

104054-27-5 structure

Name: Atipamezole
Chemical Name: 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
CAS Number: 104054-27-5
Molecular Formula: C₁₄H₁₆N₂
Molecular Weight: 212.290
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-08-11 15:22:53
Modify Date: 2024-01-05 16:27:05
Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

Name	5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
Synonyms	Atipamezolum [Latin] MPV-1248 1H-imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- 1H-Imidazole,4-(2-ethyl-2,3-dihydro-1H-inden-2-yl) Atipamezol [Spanish] 1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole Antisedan UNII-03N9U5JAF6 Atipamezole

Description	Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	Ki: 1.6 nM[1]
In Vitro	The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].
In Vivo	Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].
References	[1]. Pertovaara A, et al.Pharmacological properties, central nervous system effects, and potential therapeutic applicationsof atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11(3):273-88.

Density	1.1±0.1 g/cm3
Boiling Point	367.1±11.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₆N₂
Molecular Weight	212.290
Flash Point	178.0±5.7 °C
Exact Mass	212.131348
PSA	28.68000
LogP	3.75
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.595
Storage condition	room temp

Hazard Codes	Xi
RIDADR	NONH for all modes of transport