BW 245C
BW 245C structure
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Common Name | BW 245C | ||
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| CAS Number | 72814-32-5 | Molecular Weight | 368.468 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H32N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Genetic validation of a therapeutic target in a mouse model of ALS.
Sci. Transl. Med. 6(248) , 248ra104, (2014) Neurons produced from stem cells have emerged as a tool to identify new therapeutic targets for neurological diseases such as amyotrophic lateral sclerosis (ALS). However, it remains unclear to what extent these new mechanistic insights will translate to anim... |
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Functional antagonism of IL-1alpha induced gene expression profiles define the cAMP/PKA pathway as a unique regulator of IL-1alpha signaling networks.
J. Recept. Signal Transduct. Res. 29(5) , 246-56, (2009) Interleukin-1 (IL-1alpha) induced inflammatory and pro-fibrotic responses in human lung fibroblasts are mediated by activation of MAPK and NFkappaB pathways. The purpose of the present study was to broadly profile the activity of a variety of compounds which ... |
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Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.
J. Immunol. 175(10) , 6531-6, (2005) PGD2, produced by mast cells, has been detected in high concentrations at sites of allergic inflammation. It can stimulate vascular and other inflammatory responses by interaction with D prostanoid receptor (DP) and chemoattractant receptor-like molecule expr... |
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A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells.
Arch. Biochem. Biophys. 541 , 21-9, (2014) Indoles are composed of a common core structure, the indole ring, and are widely used as pharmaceuticals and their precursors. In this study, a newly composed relatively small indole compound, AWT-489 was examined to find a novel specific antagonist for DP re... |
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Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.
PLoS ONE 7(9) , e45273, (2012) Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail. In our experiments, prostaglandin (PG)F(2α)... |
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GIF-0173 protects against cerebral infarction through DP1 receptor activation.
Exp. Neurol. 219(2) , 481-91, (2009) The neuroprotective effects and mechanism of action of GIF-0173, a Delta12-prostaglandin J analogue, were investigated in the early phase of cerebral ischemia. GIF-0173 was administered intravenously immediately following middle cerebral artery occlusion (MCA... |
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CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine.
Pharmacology 81(3) , 236-40, (2008) The majority of prostaglandins (PGs) are known to induce intestinal fluid secretion (enteropooling). In contrast, PGD(2) has been demonstrated to inhibit fluid secretion induced by other PGs. This study was aimed to investigate, by the use of selective agonis... |
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Excitatory action of prostanoids on the ferret isolated vagus nerve preparation.
Eur. J. Pharmacol. 491(1) , 37-41, (2004) We have investigated the actions of various prostanoid receptor agonists on an isolated preparation of the ferret cervical vagus using a grease-gap extracellular recording technique. The potency ranking for depolarization was BW245C (5-(6-carboxyhexyl)-1-(3-c... |
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Implication of prostaglandin receptors in the accumulation of osteoprotegerin in human osteoblast cultures.
J. Rheumatol. 33(6) , 1167-75, (2006) Prostaglandins are important mediators in bone metabolism and in pathologies such as rheumatoid arthritis and osteoarthritis. We investigated the roles of cyclooxygenases (COX) and prostaglandin receptors in the accumulation of osteoprotegerin (OPG) in the su... |
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Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates.
J. Pharm. Pharmacol. 56(2) , 197-203, (2004) The pharmacological properties of [(3)H]-prostaglandin E(2) ([(3)H]-PGE(2)) binding to washed homogenates of hamster uterus were determined. Scatchard analysis of competition data yielded dissociation constants (K(d)s) of 30.9 +/- 5.6 nM (n = 3) and apparent ... |