3-(Biphenyl-4-yl)-5-(4-tert-butylphenyl)-4-phenyl-4H-1,2,4-triazole
3-(Biphenyl-4-yl)-5-(4-tert-butylphenyl)-4-phenyl-4H-1,2,4-triazole structure
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Common Name | 3-(Biphenyl-4-yl)-5-(4-tert-butylphenyl)-4-phenyl-4H-1,2,4-triazole | ||
|---|---|---|---|---|
| CAS Number | 150405-69-9 | Molecular Weight | 429.556 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 611.5±58.0 °C at 760 mmHg | |
| Molecular Formula | C30H27N3 | Melting Point | 231-235 ℃ | |
| MSDS | Chinese USA | Flash Point | 323.6±32.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis.
PLoS ONE 10(2) , e0118336, (2015) Oncogenic transformation is characterized by morphological changes resulting from alterations in actin dynamics and adhesive activities. Emerging evidence suggests that the protocadherin FAT4 acts as a tumor suppressor in humans, and reduced FAT4 gene express... |
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Molecular profiling and computational network analysis of TAZ-mediated mammary tumorigenesis identifies actionable therapeutic targets.
Oncotarget 5(23) , 12166-76, (2015) Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast cancer (BC) cases and contributes disproportionately to BC mortality. TAZ, a key transducer of the Hippo pathway, has recently been demonstrated to confer breast cancer stem ... |
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Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis.
Cell Cycle 14(1) , 146-56, (2015) The Hippo pathway is an evolutionarily conserved regulator of tissue growth and cell fate during development and regeneration. Conversely, deregulation of the Hippo pathway has been reported in several malignancies. Here, we used integrative functional genomi... |
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Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
Nat. Commun. 6 , 6781, (2015) Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly underst... |
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A green capillary zone electrophoresis method for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical formulations and human plasma.
Biomed. Chromatogr. 29 , 1811-8, (2015) A green, novel, rapid, accurate and reliable capillary zone electrophoresis method was developed and validated for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical preparations. Separation was carried out using fused s... |
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Functional and clinical evidence that TAZ is a candidate oncogene in hepatocellular carcinoma.
J. Cell. Biochem. 116 , 2465-75, (2015) Transcriptional co-activator with PDZ-binding motif (TAZ) has been reported to be associated with carcinogenesis. However, the cellular function of TAZ in human hepatocellular carcinoma (HCC) remains elusive. In this study, an immunohistochemistry analysis re... |
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Exogenous cardiolipin localizes to mitochondria and prevents TAZ knockdown-induced apoptosis in myeloid progenitor cells.
Biochem. Biophys. Res. Commun. 464 , 580-5, (2015) The concentration and composition of cardiolipin (CL) in mitochondria are altered in age-related heart disease, Barth Syndrome, and other rare genetic disorders, resulting in mitochondrial dysfunction. To explore whether exogenous CL can be delivered to cells... |
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A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
J. Biochem. 158 , 413-23, (2015) Transcriptional co-activator with PSD-95/Dlg-A/ZO-1 (PDZ)-binding motif (TAZ) regulates in cell proliferation and differentiation. In mesenchymal stem cells it promotes osteogenesis and myogenesis, and suppresses adipogenesis. TAZ activators are expected to p... |
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NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.
Cancer Discov. 5 , 1178-93, (2015) Ch22q LOH is preferentially associated with RAS mutations in papillary and in poorly differentiated thyroid cancer (PDTC). The 22q tumor suppressor NF2, encoding merlin, is implicated in this interaction because of its frequent loss of function in human thyro... |
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Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP.
Genes Dev. 29(12) , 1285-97, (2015) The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionar... |