alpha-methyl-dl-tyrosine methyl ester hydrochloride
alpha-methyl-dl-tyrosine methyl ester hydrochloride structure
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Common Name | alpha-methyl-dl-tyrosine methyl ester hydrochloride | ||
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| CAS Number | 7361-31-1 | Molecular Weight | 245.70300 | |
| Density | N/A | Boiling Point | 336.4ºC at 760 mmHg | |
| Molecular Formula | C11H16ClNO3 | Melting Point | 192 °C (dec.)(lit.) | |
| MSDS | USA | Flash Point | 157.2ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
Br. J. Pharmacol. 141(1) , 132-40, (2004) 1. The ORL1 agonists nociceptin and Ro 64-6198 were compared in their ability to modify spontaneous locomotor activity in male NMRI mice not habituated to the test environment. 2. Higher doses of nociceptin (>5 nmol i.c.v.) reduced whereas lower doses (<1 nmo... |
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Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.
Mol. Psychiatry 13(11) , 1028-42, (2008) Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. Both, basic and clinical studies suggested that disrupting CRH signaling through CRH type 1 receptors (CRH-R1) can ameliorate st... |
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The dopamine D3-receptor: a postsynaptic receptor inhibitory on rat locomotor activity.
J. Neural Transm. Gen. Sect. 94 , 11-19, (1993) We report on the pharmacological effects of the 20 fold D3 vs. D2 dopamine receptor preferring compound U99194A. It is shown that U99194A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the striatum or the ... |
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alpha(2)-Adrenoceptors mediate the acute inhibitory effect of fluoxetine on locus coeruleus noradrenergic neurons.
Neuropharmacology 56(6-7) , 1068-73, (2009) So far, the mechanisms underlying the action of selective serotonin reuptake inhibitors, such as fluoxetine, are not completely understood. Thus, to clarify if fluoxetine has any effect on noradrenergic transmission, we measured the spontaneous firing rate of... |
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Inhibition of ATPases enzyme activities on brain disturbing normal oestrous cycle.
Neurochem. Res. 30(3) , 315-23, (2005) Wistar rats treated with alpha-methyl-DL-p-tyrosine methylester showed significant level of inhibition in the activity of Na+, K+ -ATPase, Mg2+ -ATPase and Ca2+ -ATPase enzymes in different regions of the brain. The enzyme activity was assayed in cerebral hem... |
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Transection of carotid sinus nerve inhibits the turnover of dopamine and norepinephrine in long-term hypoxic carotid bodies: a biochemical and morphometric study.
J. Auton. Nerv. Syst. 32(2) , 165-76, (1991) To assess the efferent influence of the carotid sinus nerve on the catecholamine function and the vascularity in long-term hypoxic carotid bodies, rats were exposed to hypoxia (10% O2 in nitrogen for 1 and 3 weeks) after unilateral transection of the sinus ne... |
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Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats.
Naunyn Schmiedebergs Arch. Pharmacol. 384(1) , 39-45, (2011) Dopaminergic stabilizers may be conceptualized as drugs with normalizing effects on dopamine-mediated behaviours and neurochemical events. (S)-(-)-OSU6162 (OSU6162) and ACR16 are two structurally related compounds ascribed such properties, principally because... |
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Catecholamine depletion modulates serum LH levels, GAD67 mRNA, and GABA synthesis in the goldfish.
Gen. Comp. Endocrinol. 140(3) , 176-83, (2005) It is established that dopamine inhibits while GABA stimulates LH release in goldfish. In this study, we examine dopaminergic regulation of GABAergic activity in the hypothalamus of early recrudescent female goldfish (Carassius auratus). We utilize a unique t... |