Fludrocortisone acetate
Fludrocortisone acetate structure
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Common Name | Fludrocortisone acetate | ||
|---|---|---|---|---|
| CAS Number | 514-36-3 | Molecular Weight | 422.487 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 575.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C23H31FO6 | Melting Point | 233-234°C | |
| MSDS | Chinese USA | Flash Point | 301.6±30.1 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Importance of a suitable working protocol for tape stripping experiments on porcine ear skin: Influence of lipophilic formulations and strip adhesion impairment.
Int. J. Pharm. 491 , 162-9, (2015) The tape stripping method is a very important tool for dermopharmacokinetic experiments in vitro and the accurate measurement of the removed corneocytes is key for a reliable calculation of a drug's skin penetration behavior. Therefore, various methods to qua... |
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Dilution of semi-solid creams: influence of various production parameters on rheological properties and skin penetration.
Int. J. Pharm. 478(2) , 429-38, (2015) In order to customise treatment for patients, topical formulations are often diluted with drug-free cream bases to adjust the drug dose and thereby the formulations' activity to the patients' needs. However, the process of dilution influences properties of th... |
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Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity.
Cancer Chemother. Pharmacol. 74(2) , 249-55, (2014) A synthetic glucocorticoid, dexamethasone, was recently shown to inhibit bladder cancer cell invasion and metastasis through the glucocorticoid receptor (GR) pathway but increased cell proliferation via inhibiting apoptosis particularly induced by cisplatin. ... |
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[Fatigue, weight loss and decline in general health in a young patient. Addison disease].
Praxis (Bern 1994) 91(19) , 854-7, (2002)
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Effect of γ-cyclodextrin on the in vitro skin permeation of a steroidal drug from nanoemulsions: impact of experimental setup.
Int. J. Pharm. 423(2) , 535-42, (2012) Numerous reports on the enhancement effect of cyclodextrins (CDs) on the skin permeation of dermally applied drugs exist, the majority of which is based on in vitro diffusion cell studies. The specific experimental setup of such studies may skew the obtained ... |
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Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans.
Hypertension 46(4) , 683-8, (2005) Prostasin is a serine peptidase hypothesized to regulate epithelial sodium channel (ENaC) activity in animals or on in vitro cultured cells. We investigated whether urinary prostasin may be a candidate marker of ENaC activation in humans. We studied 10 health... |
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A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer.
Endocrinology 143(5) , 1889-900, (2002) The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth. Cortisol and ... |
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A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
Tohoku J. Exp. Med. 186(3) , 215-23, (1998) It is known that some patients with primary aldosteronism show postoperative hyperkalemia, which is due to inability of the adrenal gland to secrete sufficient amounts of aldosterone. However, hyperkalemia is generally neither severe nor prolonged, in which r... |
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Poly(epsilon-caprolactone) and Eudragit microparticles containing fludrocortisone acetate.
Int. J. Pharm. 269(2) , 491-508, (2004) Substitutive hormonal therapies have to be administered for long periods. Thus, the development of sustained-release forms, as microparticle suspensions, is interesting in order to improve patient compliance by reducing dosing frequencies and side effects. Th... |
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Effect of fludrocortisone acetate on reducing serum potassium levels in patients with end-stage renal disease undergoing haemodialysis.
Nephrol. Dial. Transplant. 22(11) , 3273-6, (2007) Hyperkalaemia is a commonly encountered problem in dialysis patients with end-stage renal disease (ESRD). The aim of the present study was to assess the effect of fludrocortisone acetate (FCA) on reducing serum potassium levels in haemodialysis (HD) patients ... |