(+/-)-Sulfinpyrazone
(+/-)-Sulfinpyrazone structure
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Common Name | (+/-)-Sulfinpyrazone | ||
|---|---|---|---|---|
| CAS Number | 57-96-5 | Molecular Weight | 404.482 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 590.8±42.0 °C at 760 mmHg | |
| Molecular Formula | C23H20N2O3S | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 311.1±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma.
PLoS ONE 9(9) , e107224, (2014) The P2X7 receptor (P2X7R) is attracting increasing attention for its involvement in cancer. Several recent studies have shown a crucial role of P2X7R in tumour cell growth, angiogenesis and invasiveness. In this study, we investigated the role of the two know... |
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MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
Mol. Cancer Ther. 7(5) , 1150-5, (2008) We used the paclitaxel-resistant human small cell lung cancer subline PC-6/TAX1-1, selected from PC-6 cells by paclitaxel, to test whether MRP7/ABCC10 (ABCC10) confers paclitaxel resistance. We found that gene expression of both ABCB1/MDR1 (ABCB1) and ABCC10 ... |
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Ascorbate uptake in pig coronary artery endothelial cells.
Mol. Cell Biochem. 271(1-2) , 43-9, (2005) Although smooth muscle and endothelial cells in pig coronary artery are morphologically and functionally distinct, ascorbate uptake has been characterized only in smooth muscle cells. Ascorbate transporters in kidney and intestinal epithelial cells differ fro... |
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Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins.
Cancer Res. 61(14) , 5461-7, (2001) We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resistance in a MCF7 breast cancer cell line selected for resistance to etoposide. The resistant cell line, MCF7/VP, expresses high levels of MRP1... |
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Free radical scavenging properties of sulfinpyrazone.
Free Radic. Res. 36(6) , 685-93, (2002) Sulfinpyrazone, a potent uricosuric drug, was tested in vitro for its scavenging action against oxygen free radicals. In this study, sulfinpyrazone was able to scavenge 1,1-diphenyl-2-picrylhydrazyl radical with IC50 value of 29.82 micrograms/ml compared to b... |
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Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide.
Free Radic. Biol. Med. 39(11) , 1449-59, (2005) To test whether ascorbic acid might be involved in the antioxidant defenses of inflammatory cells, we studied ascorbate uptake and recycling by quiescent and lipopolysaccharide-activated RAW264.7 murine macrophages. These cells concentrated ascorbate 100-fold... |
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Accumulation of intracellular ascorbate from dehydroascorbic acid by astrocytes is decreased after oxidative stress and restored by propofol.
Glia 39(2) , 124-32, (2002) Primary rat astrocyte cultures absorbed dehydroascorbic acid from the medium and reduced it to intracellular ascorbate. Uptake of dehydroascorbic acid (5-200 microM) was inhibited only partially by glucose (10 mM). The remaining glucose-insensitive component ... |
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Sulfinpyrazone C-glucuronidation is catalyzed selectively by human UDP-glucuronosyltransferase 1A9.
Drug Metab. Dispos. 34(12) , 1950-3, (2006) The uricosuric agent sulfinpyrazone (SFZ) is metabolized via C-glucuronidation, an uncommon metabolic pathway, in humans. The present study aimed to characterize SFZ glucuronidation by human liver microsomes (HLMs) and identify the hepatic forms of UDP-glucur... |
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Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
Nephrology (Carlton.) 16(2) , 156-62, (2011) Hyperuricaemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases. The kidney plays a dominant role in maintaining plasma urate levels through the excretion process. Human renal urate transporter URAT1 is thought to b... |
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Molecular epidemiology of malaria in Cameroon. XXVI. Twelve-year in vitro and molecular surveillance of pyrimethamine resistance and experimental studies to modulate pyrimethamine resistance.
Am. J. Trop. Med. Hyg. 77(2) , 221-7, (2007) In vitro pyrimethamine response of Plasmodium falciparum isolates and dihydrofolate reductase (dhfr) gene sequences were analyzed in 2004-2005 and compared with our previous data. Most isolates (n = 103, all dhfr mutants) had 50% inhibitory concentrations (IC... |