1-Fluoro-2,4-dinitrobenzene
1-Fluoro-2,4-dinitrobenzene structure
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Common Name | 1-Fluoro-2,4-dinitrobenzene | ||
|---|---|---|---|---|
| CAS Number | 70-34-8 | Molecular Weight | 186.097 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 296.0±20.0 °C at 760 mmHg | |
| Molecular Formula | C6H3FN2O4 | Melting Point | 25-27 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 132.8±21.8 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.
J. Exp. Med. 211(13) , 2549-66, (2014) DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear defo... |
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Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.
J. Invest. Dermatol. 134(11) , 2709-18, (2014) Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. He... |
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Depletion of regulatory T cells in a hapten-induced inflammation model results in prolonged and increased inflammation driven by T cells.
Clin. Exp. Immunol. 179(3) , 485-99, (2015) Regulatory T cells (Tregs ) are known to play an immunosuppressive role in the response of contact hypersensitivity (CHS), but neither the dynamics of Tregs during the CHS response nor the exaggerated inflammatory response after depletion of Tregs has been ch... |
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Hydrogel-gauze dressing for moderate-to-severe atopic dermatitis: development and efficacy study on atopic dermatitis-like skin lesions in NC/Nga mice.
Drug Dev. Ind. Pharm. 40(11) , 1538-46, (2014) Topical emollients are known to provide symptomatic relief for atopic dermatitis. In hospitals, wet-wrap therapy has been shown to benefit children with moderate-to-severe atopic dermatitis (AD), but the application of wet-wraps is tedious and time-consuming.... |
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Downregulation of immunological mediators in 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions by hydrocortisone-loaded chitosan nanoparticles.
Int. J. Nanomedicine 9 , 5143-56, (2014) Atopic dermatitis is a chronic, noncontiguous, and exudative disorder accompanied by perivascular infiltration of immune mediators, including T-helper (Type 1 helper/Type 2 helper) cells, mast cells, and immunoglobulin E. The current study explores the immuno... |
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Skin sensitization induced Langerhans' cell mobilization: variable requirements for tumour necrosis factor-α.
Immunology 144(1) , 139-48, (2015) Upon antigen/allergen recognition, epidermal Langerhans' cells (LC) are mobilized and migrate to the local lymph node where they play a major role in initiating or regulating immune responses. It had been proposed that all chemical allergens induce LC migrati... |
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Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.
J. Neurosci. 35(14) , 5707-23, (2015) The distribution of mitochondria within mature, differentiated neurons is clearly adapted to their regional physiological needs and can be perturbed under various pathological conditions, but the function of mitochondria in developing neurons has been less we... |
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Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin.
Toxicol. Lett. 237 , 11-20, (2015) Glutathione (GSH) is the most prominent antioxidant in cells and the co-factor of an important set of enzymes involved in the skin metabolic clearance system, glutathione S-transferases (GST). Here, we describe an LC-MS (liquid chromatography-mass spectroscop... |
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Improvement of derivatized amino acid detection sensitivity in micellar electrokinetic capillary chromatography by means of acid-induced pH-mediated stacking technique.
Anal. Bioanal. Chem 406(26) , 6713-21, (2014) Derivatization is a frequently used sample preparation procedure applicable to the enhancement of analyte detection sensitivity. Amino acids mostly require derivatization prior to electrophoretic or chromatographic analysis, especially if spectrophotometric d... |
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Topical Lyogel Containing Corticosteroid Decreases IgE Expression and Enhances the Therapeutic Efficacy Against Atopic Eczema.
AAPS PharmSciTech 16 , 656-63, (2015) Hydrocortisone cream intended for atopic eczema often produces unwanted side effects after long-term use. These side effects are essentially due to repeated percutaneous administration of the medication for skin dermatitis, as atopic eczema is a relapsing dis... |