1,3-Diphenyl-2-propen-1-one
1,3-Diphenyl-2-propen-1-one structure
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Common Name | 1,3-Diphenyl-2-propen-1-one | ||
|---|---|---|---|---|
| CAS Number | 94-41-7 | Molecular Weight | 208.25500 | |
| Density | N/A | Boiling Point | 208 °C25 mm Hg(lit.) | |
| Molecular Formula | C15H12O | Melting Point | 55-59 °C | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach.
Molecules 20 , 8072-93, (2015) Tuberculosis (TB) remains a serious public health problem aggravated by the emergence of M. tuberculosis (Mtb) strains resistant to multiple drugs (MDR). Delay in TB treatment, common in the MDR-TB cases, can lead to deleterious life-threatening inflammation ... |
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Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.
Molecules 17(11) , 12925-37, (2012) A high performance liquid chromatographic (HPLC) method with diode array detection (DAD) was established for simultaneous determination of seven main bioactive components in San-ao decoction and its series of formulae (San-ao decoction, Wu-ao decoction, Qi-ao... |
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Development of a stability-indicating LC method for determination of a synthetic chalcone derivative in a nanoemulsion dosage form and identification of the main photodegradation product by LC-MS.
J. Pharm. Biomed. Anal. 70 , 652-6, (2012) This study aimed to develop and validate a stability indicating LC for the determination of 5-(2-benzoylethenyl)-N-benzyl-2 methoxybenzenesulfonamide (SCD - a synthetic chalcone derivative), and evaluate the degradation profile of the compound under different... |
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Bifendate-chalcone hybrids: a new class of potential dual inhibitors of P-glycoprotein and breast cancer resistance protein.
Biochem. Biophys. Res. Commun. 455(3-4) , 318-22, (2014) We previously described bifendate-chalcone hybrids as potent P-glycoprotein inhibitors. In the present work, we determine whether these compounds could reverse breast cancer resistance protein (BCRP, ABCG2)-mediated multidrug resistance using HEK293/BCRP cell... |
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Inhibitory effects of hydroxysafflor yellow A on the formation of advanced glycation end products in vitro.
Biol. Pharm. Bull. 35(11) , 2050-3, (2012) To investigate the inhibitory effects of hydroxysafflor yellow A (HSYA) on the protein glycation in vitro. Using bovine serum albumin (BSA)-glucose assay, BSA-methylglyoxal (MGO) assay, and N-acetylglycyl-lysine methyl ester (G.K.) peptide-ribose assay, inhib... |
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Hydroxysafflor yellow A suppresses oleic acid-induced acute lung injury via protein kinase A.
Toxicol. Appl. Pharmacol. 272(3) , 895-904, (2013) Inflammation response and oxidative stress play important roles in acute lung injury (ALI). Activation of the cAMP/protein kinase A (PKA) signaling pathway may attenuate ALI by suppressing immune responses and inhibiting the generation of reactive oxygen spec... |
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Synthesis of some quinolinyl chalcone analogues and investigation of their anticancer and synergistic anticancer effect with doxorubicin.
Bioorg. Khim. 38(4) , 489-95, (2012) Two derivatives of 2-(4-acetylanilino)quinolines (IIIa, b) were synthesized as scaffolds for synthesis of open chalcone analogues (Va-f) through Claisen-Schmidt condensation with a set of aromatic aldehydes (IVa-d). Derivatives (Va, b) were further manipulate... |
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Investigations on the physico chemical properties of 4-bromochalcone single crystals for nonlinear optical applications.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 103 , 45-52, (2013) Good quality yellow transparent single crystals of 4-bromochalcone (4BC) crystal have been synthesized and grown by slow evaporation solution growth method. The UV-Vis spectra was recorded for the grown crystal. The thermal behavior of the title crystal was s... |
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Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.
Eur. J. Med. Chem. 56 , 203-9, (2012) Four novel series of compounds, including the l-phenylalanine-derived C5-substituted rhodanine (6a-q, 7a-j) and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone (9a-e, 11a-e) have been designed, synthesized, characterized, and ... |
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The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model.
Molecules 18(2) , 1693-703, (2013) Alzheimer's disease (AD) pathogenesis involves an imbalance between free radical formation and destruction. In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free rad... |