6-Carboxyfluorescein Diacetate

6-Carboxyfluorescein Diacetate Structure
6-Carboxyfluorescein Diacetate structure
Common Name 6-Carboxyfluorescein Diacetate
CAS Number 3348-03-6 Molecular Weight 460.389
Density 1.6±0.1 g/cm3 Boiling Point 701.6±60.0 °C at 760 mmHg
Molecular Formula C25H16O9 Melting Point 152–153°C
MSDS Chinese USA Flash Point 245.1±26.4 °C

Critical-size bone defect repair using amniotic fluid stem cell/collagen constructs: effect of oral ferutinin treatment in rats.

Life Sci. 121 , 174-83, (2015)

This study aims to evaluate the bone regeneration in a rat calvarias critical size bone defect treated with a construct consisting of collagen type I and human amniotic fluid stem cells (AFSCs) after oral administration of phytoestrogen ferutinin.In 12 week o...

Substrate stress relaxation regulates cell spreading.

Nat. Commun. 6 , 6364, (2015)

Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the ECM. However, these studies typically utilize purely elastic materials a...

Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.

J. Cell Biol. 211 , 881-96, (2015)

Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stre...

Physical Routes to Primitive Cells: An Experimental Model Based on the Spontaneous Entrapment of Enzymes inside Micrometer-Sized Liposomes.

Life (Basel) 5 , 969-96, (2015)

How did primitive living cells originate? The formation of early cells, which were probably solute-filled vesicles capable of performing a rudimentary metabolism (and possibly self-reproduction), is still one of the big unsolved questions in origin of life. W...

Triggering enzymatic activity with force.

Nano Lett. 9(9) , 3290-5, (2009)

Integrating single molecule force spectroscopy with fluorescence-based techniques allows the manipulation of an enzyme with a periodic stretching and relaxation protocol while simultaneously monitoring its catalytic activity. After releasing the stretching fo...

Helium generated cold plasma finely regulates activation of human fibroblast-like primary cells.

PLoS ONE 9(8) , e104397, (2014)

Non-thermal atmospheric pressure plasmas are being developed for a wide range of health care applications, including wound healing. However in order to exploit the potential of plasma for clinical applications, the understanding of the mechanisms involved in ...

BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming.

PLoS Pathog. 11 , e1005206, (2015)

The transport of antigen from the periphery to the draining lymph node (DLN) is critical for T-cell priming but remains poorly studied during infection with Mycobacterium bovis Bacille Calmette-Guérin (BCG). To address this we employed a mouse model to track ...

Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro.

Mol. Immunol. 60(1) , 32-43, (2014)

Liver X receptors (LXRs) are nuclear receptors that play an essential role in lipid and cholesterol metabolism. Emerging studies indicate a potential function for LXRs in regulating dendritic cell (DC)-dependent immune responses; however, the role of LXRs in ...

Ribavirin enhances myeloid-derived suppressor cell differentiation through CXCL9/10 downregulation.

Immunopharmacol. Immunotoxicol. 36(6) , 412-9, (2014)

Elevation of myeloid-derived suppressor cells (MDSCs) was observed in some viral infectious diseases. In this study, we studied whether ribavirin, a widely used clinical antiviral drug, could impact the differentiation of human MDSCs in vitro. Flow cytometric...

The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis.

PLoS ONE 10 , e0132463, (2015)

A high prevalence of thyroid papillary cancer was reported in hepatitis-C-virus (HCV) positive patients. However, the mechanistic role of hepatic-fibrosis in thyroid malignancy progressions is still unclear.We aimed to study the immune-modulatory interactions...