3348-03-6

3348-03-6 structure

Name: 6-Carboxyfluorescein Diacetate
Chemical Name: 6-carboxyfluorescein diacetate
CAS Number: 3348-03-6
Molecular Formula: C₂₅H₁₆O₉
Molecular Weight: 460.389
Catalog: Dye Reagents
Create Date: 2018-07-12 19:51:11
Modify Date: 2025-08-22 06:03:03
6-CFDA is fluorescent polyanionic probe, and its derivatives such as 2′,7′-bis (2-carboxyethyl)-5(6)-carboxyfluorescein are used to measure changes in intracellular pH (pHi) and processes such as dendrimer aggregation and absorption.

Name	6-carboxyfluorescein diacetate
Synonyms	6-FAM DA 6-CFDA 6-Carboxy-di-O-acetylfluorescein 6-CFDA MFCD00036871 6-Carboxyfluorescein diacetate 3',6'-Diacetoxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid 6-Carboxy-di-O-acetylfluorescein,6-CFDA 5,6-diacetyl FAM-SE 6-CARBOXY-DI-O-ACETYLFLUORESCEIN Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid, 3',6'-bis(acetyloxy)-3-oxo- 3',6'-Diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid 6-FAM DIACETATE 6-Carboxyfluorescein diacetate,6-CFDA,6-Carboxy-di-O-acetylfluorescein 6-CARBOXYFLUORESCEINE DIACETATE

Description	6-CFDA is fluorescent polyanionic probe, and its derivatives such as 2′,7′-bis (2-carboxyethyl)-5(6)-carboxyfluorescein are used to measure changes in intracellular pH (pHi) and processes such as dendrimer aggregation and absorption.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Dye Reagents
References	[1]. Babcock DF. Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J Biol Chem. 1983 May 25;258(10):6380-9. [2]. Graber ML, et al. Characteristics of fluoroprobes for measuring intracellular pH. Anal Biochem. 1986 Jul;156(1):202-12. [3]. Bonizzoni M, et al. PAMAM dendrimer-induced aggregation of 5(6)-carboxyfluorescein. J Org Chem. 2012 Feb 3;77(3):1258-66.

Density	1.6±0.1 g/cm3
Boiling Point	701.6±60.0 °C at 760 mmHg
Melting Point	152–153°C
Molecular Formula	C₂₅H₁₆O₉
Molecular Weight	460.389
Flash Point	245.1±26.4 °C
Exact Mass	460.079437
PSA	125.43000
LogP	2.45
Appearance	Light yellow or off-white solid
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.702
Storage condition	2-8°C
Water Solubility	DMSO: soluble

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932999099

108-24-7

76608-15-6

3348-03-6

Literature: US2013/65263 A1, ; Paragraph 0083; 0084 ;

Precursor 2
108-24-7 76608-15-6
DownStream 0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%