(+/-)-JQ1
(+/-)-JQ1 structure
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Common Name | (+/-)-JQ1 | ||
|---|---|---|---|---|
| CAS Number | 1268524-69-1 | Molecular Weight | 456.98800 | |
| Density | 1.33±0.1 g/cm3(Predicted) | Boiling Point | 610.4±65.0 °C(Predicted) | |
| Molecular Formula | C23H25ClN4O2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Selective inhibition of BET bromodomains.
Nature 468(7327) , 1067-73, (2010) Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Potent inhibitors of histone binding modules have not yet been ... |
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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
Nature 510(7504) , 278-82, (2014) Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of rece... |
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