(+/-)-JQ1
(+/-)-JQ1 structure
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Common Name | (+/-)-JQ1 | ||
|---|---|---|---|---|
| CAS Number | 1268524-69-1 | Molecular Weight | 456.98800 | |
| Density | 1.33±0.1 g/cm3(Predicted) | Boiling Point | 610.4±65.0 °C(Predicted) | |
| Molecular Formula | C23H25ClN4O2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Name | tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
|---|---|
| Synonym | More Synonyms |
| Density | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 610.4±65.0 °C(Predicted) |
| Molecular Formula | C23H25ClN4O2S |
| Molecular Weight | 456.98800 |
| Exact Mass | 456.13900 |
| PSA | 97.61000 |
| LogP | 4.96690 |
| Appearance of Characters | powder，white to beige |
| RIDADR | NONH for all modes of transport |
|---|
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~%
(+/-)-JQ1 CAS#:1268524-69-1 |
| Literature: Zhang, Chong-Jing; Tan, Chelsea Y. J.; Ge, Jingyan; Na, Zhenkun; Chen, Grace Y. J.; Uttamchandani, Mahesh; Sun, Hongyan; Yao, Shao Q. Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14060 - 14064Angew. Chem., 2013 , vol. 125, # 52 p. 14310 - 14314,5 |
![1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-dimethyl-2-oxo-, 1,1-dimethylethyl ester, (3S)- structure](https://image.chemsrc.com/caspic/054/1268524-67-9.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
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Selective inhibition of BET bromodomains.
Nature 468(7327) , 1067-73, (2010) Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Pote... |
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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
Nature 510(7504) , 278-82, (2014) Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated and... |
| MFCD23726614 |