2-Phenylindole
2-Phenylindole structure
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Common Name | 2-Phenylindole | ||
|---|---|---|---|---|
| CAS Number | 948-65-2 | Molecular Weight | 193.244 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 419.9±0.0 °C at 760 mmHg | |
| Molecular Formula | C14H11N | Melting Point | 188-190 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 176.6±11.9 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.
J. Pineal Res. 58(3) , 310-20, (2015) Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In this study, we show that melatonin enhances tunicamycin-in... |
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The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.
PLoS Genet. 10(9) , e1004659, (2014) The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various subst... |
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Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.
PLoS ONE 10(2) , e0118188, (2015) Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can induce new ne... |
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Differential regulation of caspase-2 in MPP⁺-induced apoptosis in primary cortical neurons.
Exp. Cell Res. 332(1) , 60-6, (2015) Parkinson's disease (PD), among the most common neurodegenerative diseases worldwide for which there is no cure, is characterized as progressive dopaminergic neuron loss in the substantia nigra through an unknown mechanism. Administering 1-methyl-4-phenyl-1, ... |
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Dual growth factor-immobilized microspheres for tissue reinnervation: in vitro and preliminary in vivo studies.
J. Biomater. Sci. Polym. Ed. 26(5) , 322-37, (2015) Growth factors (GFs) (basic fibroblast growth factor (bFGF) and/or nerve growth factor (NGF))-immobilized polycaprolactone (PCL)/Pluronic F127 microspheres were prepared using an isolated particulate-melting method and the sequential binding of heparin and GF... |
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Synergism of arsenic trioxide and MG132 in Raji cells attained by targeting BNIP3, autophagy, and mitochondria with low doses of valproic acid and vincristine.
Eur. J. Cancer 50(18) , 3243-61, (2014) We previously demonstrated that arsenic trioxide (ATO) and proteasome inhibitor MG132 synergistically induced cell death in promonocytic leukaemia cell line U937 but were antagonistic in Burkitt's lymphoma cell line Raji. Here we explore the role of autophagy... |
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GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination.
J. Neurosci. Res. 93(2) , 285-95, (2014) The γ-aminobutyric acid (GABA) type B receptor has been implicated in glial cell development in the peripheral nervous system (PNS), although the exact function of GABA signaling is not known. To investigate GABA and its B receptor in PNS development and dege... |
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Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma.
Anticancer Res. 35(1) , 169-74, (2014) The tumor suppressor gene p53 is mutated in glioblastoma. We studied the relationship between the p53 gene and the biological effects of boron neutron capture therapy (BNCT).The human glioblastoma cells; A172, expressing wild-type p53, and T98G, with mutant p... |
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Serum gastrin-releasing peptide levels correlate with pruritus in patients with atopic dermatitis.
Scand. J. Gastroenterol. 50(3) , 321-32, (2015)
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Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles.
Pharm. Res. 32 , 2280-91, (2015) A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellula... |