Reversan
Reversan structure
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Common Name | Reversan | ||
|---|---|---|---|---|
| CAS Number | 313397-13-6 | Molecular Weight | 441.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H27N5O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication.
Hepatology 62 , 397-408, (2015) Hepatitis A virus (HAV) and hepatitis C virus (HCV) are two positive-strand RNA viruses sharing a similar biology, but causing opposing infection outcomes, with HAV always being cleared and HCV establishing persistence in the majority of infections. To gain d... |
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Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.
Mol. Cancer Ther. 14 , 952-63, (2015) Antibody-drug conjugates (ADC) are emerging as clinically effective therapy. We hypothesized that cancers treated with ADCs would acquire resistance mechanisms unique to immunoconjugate therapy and that changing ADC components may overcome resistance. Breast ... |
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ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.
J. Natl. Cancer Inst. 103 , 1236-51, (2011) Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their role in cytotoxic drug efflux, certain observations have suggested that these multidrug transporters might con... |
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Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.
Cancer Res. 69 , 6573-6580, (2009) The multidrug resistance-associated protein 1 (MRP1) has been closely linked to poor treatment response in several cancers, most notably neuroblastoma. Homozygous deletion of the MRP1 gene in primary murine neuroblastoma tumors resulted in increased sensitivi... |