SR 11237
SR 11237 structure
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Common Name | SR 11237 | ||
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| CAS Number | 146670-40-8 | Molecular Weight | 380.47700 | |
| Density | 1.139g/cm3 | Boiling Point | 499.9ºC at 760 mmHg | |
| Molecular Formula | C24H28O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 167.1ºC | |
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Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma.
J. Invest. Dermatol. 135 , 2102-8, (2015) Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of vitamin A embody an effective CTCL therapy with over three... |
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Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin.
Toxicol. Appl. Pharmacol. 294 , 32-42, (2016) One proposed contributing factor to the rise in overweight and obesity is exposure to endocrine disrupting chemicals. Tributyltin chloride (TBT), an organotin, induces adipogenesis in cell culture models and may increases adipose mass in vivo in vertebrate mo... |
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Detection of a receptor-ligand non-covalent complex using a triple quadrupole mass spectrometer.
Rapid Commun. Mass Spectrom. 16(20) , 2003-6, (2002)
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The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights.
PLoS ONE 5(11) , e15119, (2010) Retinoic acid receptors (RARs) and Retinoid X nuclear receptors (RXRs) are ligand-dependent transcriptional modulators that execute their biological action through the generation of functional heterodimers. RXR acts as an obligate dimer partner in many signal... |
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Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.
Proc. Natl. Acad. Sci. U. S. A. 93(5) , 1803-7, (1996) Retinoids exert pleiotropic effects on the development of vertebrates through the action of retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the effect of synthetic retinoids selective for RXR and RAR on the development of Xe... |
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Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling.
Microbes Infect. 16(2) , 114-22, (2014) Using a high-throughput screening system involving HCV JFH-1-Huh 7.5.1 cells, we determined that the ligands of class II nuclear receptors, retinoids and rexinoids inhibit HCV infection. Retinoids, ligands of retinoic acid receptor (RAR), and rexinoids, ligan... |
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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.
Mol. Cell. 5(2) , 289-98, (2000) The crystal structure of a heterodimer between the ligand-binding domains (LBDs) of the human RARalpha bound to a selective antagonist and the constitutively active mouse RXRalphaF318A mutant shows that, pushed by a bulky extension of the ligand, RARalpha hel... |
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RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
EMBO J. 18(24) , 7011-8, (1999) Although retinoic acid receptor alpha (RARalpha) agonists induce the maturation of t(15;17) acute promyelocytic leukemia (APL) cells, drug treatment also selects leukemic blasts expressing PML-RARalpha fusion proteins with mutated ligand-binding domains that ... |
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[Effect of retinoid X receptor activation on oxidized low-density lipoprotein induced cell differentiation of murine macrophage cell line into dendritic like cells].
Zhonghua Xin Xue Guan Bing Za Zhi 35(9) , 833-7, (2007) To investigate the effect and related mechanism of retinoid X receptor (RXR) activation on oxidized low-density lipoprotein (ox-LDL) induced differentiation of macrophage into dendritic cell.RAW264.7 murine macrophage cell line was cultured with ox-LDL for 48... |
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Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.
ChemMedChem 4(7) , 1143-52, (2009) C/Si switch: Twofold sila-substitution (C/Si exchange) in the RXR-selective retinoids 4 a (SR11237) and 5 a leads to 4 b (disila-SR11237) and 5 b, respectively. Chemistry and biology of the C/Si pairs are reported.SR11237 (BMS649, 4 a) is a pan-RXR-selective ... |