L-750667
L-750667 structure
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Common Name | L-750667 | ||
|---|---|---|---|---|
| CAS Number | 1021868-80-3 | Molecular Weight | 527.65800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H22Cl3IN4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology.
Mol. Pharmacol. 57 , 144-152, (2000) The molecular determinants that govern selective ligand binding to the rat D(4) dopamine receptor were investigated by substituting D(2) dopamine receptor sequences into a D(4) dopamine receptor background. The resulting mutant D(4) dopamine receptors were th... |
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3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
J. Med. Chem. 39 , 1941, (1996)
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Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia.
Circulation 111 , 356-62, (2005) Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. We investigated whether AM enhances bone marrow cell-induced angiogenesis.Immediately after hindlimb ischemia was created, rats were ra... |
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Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.
Mol. Pharmacol. 50 , 1658, (1996) We identified a novel azaindole derivative, L-750,667, that has high affinity (Ki = 0.51 nM) and >2000-fold selectivity for D4 dopamine receptors compared with its activity at D2 and D3 dopamine receptors. L-750,667 had little affinity for rat D1/D5 dopamine ... |
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RamA, a member of the AraC/XylS family, influences both virulence and efflux in Salmonella enterica serovar Typhimurium.
J. Bacteriol. 192 , 1607-16, (2010) The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 lacking a functional ramA or ramR or with plasmid-mediated high-level overexpression of ramA were compared to those of the wild-type parental strain. Inactivation of ramA led to increased ex... |
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Disulfide cross-linking indicates that FlgM-bound and free sigma28 adopt similar conformations.
Proc. Natl. Acad. Sci. U. S. A. 103 , 16722-7, (2006) The dissociable sigma subunit of bacterial RNA polymerase is required for the promoter-specific initiation of transcription. When bound to RNA polymerase, sigma makes sequence-specific promoter contacts and plays a crucial role in DNA melting. In isolation, h... |