Omeprazole Sulfone
Omeprazole Sulfone structure
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Common Name | Omeprazole Sulfone | ||
|---|---|---|---|---|
| CAS Number | 88546-55-8 | Molecular Weight | 361.415 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 599.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H19N3O4S | Melting Point | 80-82ºC | |
| MSDS | Chinese USA | Flash Point | 316.2±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Pharmacokinetics of omeprazole and its metabolites in three phases of menstrual cycle.
Eur. J. Drug Metab. Pharmacokinet. 40(1) , 13-22, (2015) Omeprazole (OMP) is effective in the treatment of gastric hyperacidity and is metabolized by CYP2C19 and CYP3A4. These enzymes are modulated by estrogen and progesterone which regulate the menstrual cycle. The variations in the pharmacokinetics (PK) of many d... |
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CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.
J. Clin. Pharm. Ther. 34(4) , 437-46, (2009) CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The... |
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Metabolism of omeprazole after two oral doses in children 1 to 9 months old.
Proc. West. Pharmacol. Soc. 48 , 108-9, (2005) Essential oils from onion (Allium cepa L.), garlic (Allium sativum L.), and their main components, such as propyl thiosulfinate oxide (PTSO) are being intended for active packaging with the purpose of maintaining and extending food product quality and shelf l... |
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The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics.
Clin. Pharmacokinet. 44(11) , 1179-89, (2005) The metabolic activity of cytochrome P450 (CYP) 2C19 is genetically determined, and the pharmacokinetics of omeprazole, a substrate for CYP2C19, are dependent on the CYP2C19 genotype. However, a discrepancy between the CYP2C19 genotype and omeprazole pharmaco... |
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Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography.
J. Pharm. Biomed. Anal. 42(1) , 100-6, (2006) A sensitive method for the determination of omeprazole and its metabolites has been developed. It involves an automated solid phase extraction (SPE) procedure and capillary electrophoresis with UV detection. Omeprazole, hydroxyomeprazole and omeprazole sulfon... |
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Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole.
Acta Pharmacol. Sin. 28(10) , 1685-92, (2007) To explore the potential interactions between yin zhi huang (YZH) and omeprazole, a substrate of CYP3A4 and CYP2C19.Eighteen healthy volunteers, including 6 CYP2C19*1/*1, 6 CYP2C19*1/*2 or *3 and 6 CYP2C19*2/*2 were enrolled in a 2-phase, randomized, crossove... |
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Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole.
J. Chromatogr. A. 1156(1-2) , 201-5, (2007) To guarantee that an analytical procedure gives reliable, exact and interpretable information about a sample, it must be validated. Two ambiguous parameters are detection limit and quantification limit. The determination of these limits is still of great conc... |
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Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data.
Clin. Pharmacol. Ther. 78(6) , 627-34, (2005) The clinical outcome of acid-related disorders treated by proton pump inhibitors (PPIs) might be dependent on the polymorphically expressed cytochrome P450 (CYP) 2C19, which is involved in PPI metabolism. We tested whether esomeprazole-induced healing of gast... |
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Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.
Eur. J. Clin. Pharmacol. 68(4) , 407-13, (2012) To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cytochrome ... |
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Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes.
Basic Clin Pharmacol Toxicol. 95(3) , 112-9, (2004) This study aimed to investigate the effect of omeprazole on intragastric pH and gastrin release as well as the plasma concentration of omeprazole in relation to CYP2C19 genotypes after repeated doses in Korean patients. Twenty-six Korean patients with acid re... |