Scopolamine hydrobromide trihydrate
Scopolamine hydrobromide trihydrate structure
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Common Name | Scopolamine hydrobromide trihydrate | ||
|---|---|---|---|---|
| CAS Number | 6533-68-2 | Molecular Weight | 438.311 | |
| Density | 1.31 g/cm3 | Boiling Point | 460.3ºC at 760 mmHg | |
| Molecular Formula | C17H28BrNO7 | Melting Point | 197-194 °C | |
| MSDS | Chinese USA | Flash Point | 232.2ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Dry eye predisposes to corneal neovascularization and lymphangiogenesis after corneal injury in a murine model.
Cornea 33(6) , 621-7, (2014) Dry eye disease is becoming recognized as an immune-inflammation mediated disorder. Surgical insults such as corneal incision or suture can aggravate dry eye. We sought to determine whether underlying dry eye aggravates corneal inflammatory infiltration, hema... |
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Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice.
Pharmacol. Biochem. Behav. 134 , 57-64, (2015) 5-Hydroxymethyl-2-furaldehyde (5-HMF) is a compound derived from the dehydration of certain sugars. The aim of the present study was to evaluate the effect of 5-HMF on the cognitive impairment induced by scopolamine, a muscarinic receptor antagonist. To measu... |
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Deer bone extract prevents against scopolamine-induced memory impairment in mice.
J. Med. Food 18(2) , 157-65, (2015) Deer bone has been used as a health-enhancing food as well as an antiaging agent in traditional Oriental medicine. Recently, the water extract of deer bone (DBE) showed a neuroprotective action against glutamate or Aβ1-42-induced cell death of mouse hippocamp... |
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Effect of Topical 5-Aminoimidazole-4-carboxamide-1-β-d-Ribofuranoside in a Mouse Model of Experimental Dry Eye.
Invest. Ophthalmol. Vis. Sci. 56 , 3149-58, (2015) To investigate the efficacy of topical 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) in a mouse model of experimental dry eye (EDE).Eye drops consisting of 0.001% or 0.01% AICAR, 0.05% cyclosporine A (CsA), or balanced salt solution (BSS) were a... |
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VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum.
Am. J. Physiol. Gastrointest. Liver Physiol. 306(9) , G748-58, (2014) In the gastrointestinal tract, vasoactive intestinal peptide (VIP) is found exclusively within neurons. VIP regulates intestinal motility via neurally mediated and direct actions on smooth muscle and secretion by a direct mucosal action, and via actions on su... |
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Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model.
Mol. Vis. 21 , 1210-23, (2015) The occurrence of repetitive dry eye is accompanied by inflammation. This study investigated the anti-inflammatory effects of chondrocyte-derived extracellular matrix (CDECM) on the cornea and conjunctiva in a dry eye mouse model.Dry eyes were experimentally ... |
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The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
J. Pharmacol. Exp. Ther. 351(2) , 390-402, (2014) A subset of angiotensin IV (AngIV)-related molecules are known to possess procognitive/antidementia properties and have been considered as templates for potential therapeutics. However, this potential has not been realized because of two factors: 1) a lack of... |
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Expression of SIRT1 and oxidative stress in diabetic dry eye.
Int. J. Clin. Exp. Pathol. 8 , 7644-53, (2015) To explore the expression of SIRT1 with oxidative stress and observe physiological and pathological changes in the corneas as well as the association between SIRT1 and oxidative stress of diabetic dry eyes in mice.Forty-eight C57BL/6Jdb/db mice at eight weeks... |
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Identification and quantification of 34 drugs and toxic compounds in blood, urine, and gastric content using liquid chromatography with tandem mass spectrometry.
J. Sep. Sci. 38 , 1680-90, (2015) A liquid chromatography with tandem mass spectrometry method was developed for the simultaneous screening of 34 drugs and poisons in forensic cases. Blood (0.5 mL, diluted 1:1 with water) or 1.0 mL of urine was purified by solid-phase extraction. Gastric cont... |
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Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways.
Behav. Brain Res. 281 , 86-95, (2015) Disorders characterized by disturbed cholinergic signaling, such as schizophrenia, exhibit impaired performance on measures of real-world cost/benefit decision-making. Whether the cholinergic system contributes to the choice deficits observed is currently unk... |