Paraxanthine
Paraxanthine structure
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Common Name | Paraxanthine | ||
|---|---|---|---|---|
| CAS Number | 611-59-6 | Molecular Weight | 180.16400 | |
| Density | 1.6 g/cm3 | Boiling Point | 312.97°C (rough estimate) | |
| Molecular Formula | C7H8N4O2 | Melting Point | 294-296ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 9℃ | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster.
PLoS ONE 10(2) , e0117328, (2015) Caffeine (1, 3, 7-trimethylxanthine), an alkaloid produced by plants, has antioxidant and insecticide properties that can affect metabolism and cognition. In vertebrates, the metabolites derived from caffeine have been identified, and their functions have bee... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Potassium-based algorithm allows correction for the hematocrit bias in quantitative analysis of caffeine and its major metabolite in dried blood spots.
Anal. Bioanal. Chem 406(26) , 6749-55, (2014) Although dried blood spot (DBS) sampling is increasingly receiving interest as a potential alternative to traditional blood sampling, the impact of hematocrit (Hct) on DBS results is limiting its final breakthrough in routine bioanalysis. To predict the Hct o... |
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Why dried blood spots are an ideal tool for CYP1A2 phenotyping.
Clin. Pharmacokinet. 53(8) , 763-71, (2014) Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies. However, all of the available phenotyping studies used small datasets and did ... |
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Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.
Toxicol. Lett. 241 , 82-94, (2015) New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) including alpha-methyl tryptamines (AMTs), dimethyl tryptamines... |
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Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method.
Clin. Pharmacol. Ther. 94(6) , 702-8, (2013) Cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A are major factors involved in the metabolism of clinically prescribed drugs. Because the time course after drug treatment discontinuation has received little attention, we aimed to clarify the chro... |
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Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.
Clin. Pharmacokinet. 55 , 79-91, (2016) Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of... |
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The impact of different proportions of a treated effluent on the biotransformation of selected micro-contaminants in river water microcosms.
Int. J. Environ. Res. Public Health 11(10) , 10390-405, (2014) Attenuation of micro-contaminants is a very complex field in environmental science and evidence suggests that biodegradation rates of micro-contaminants in the aqueous environment depend on the water matrix. The focus of the study presented here is the system... |
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HPLC method for urinary theobromine determination: Effect of consumption of cocoa products on theobromine urinary excretion in children.
Clin. Biochem. 48 , 1138-43, (2015) To validate a simple method of urinary theobromine determination, to assess urinary theobromine levels in 80 healthy children and to relate these levels to consumption of cocoa products.Urine samples were diluted, directly injected into an HPLC system, separa... |
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Polymorphisms of CYP1A2 and CYP2A6 activity: phenotypes and the effect of age and sex in a Nigerian population.
Drug Metabol Personal Ther 30 , 203-10, (2015) CYP1A2 and CYP2A6 are polymorphic enzymes that metabolise several compounds of clinical importance. This study investigated the prevalent phenotypes of these enzymes and the influence of age and sex on enzyme activity in a Nigerian population.Caffeine (110 mg... |