alpha-Amyrin
alpha-Amyrin structure
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Common Name | alpha-Amyrin | ||
|---|---|---|---|---|
| CAS Number | 638-95-9 | Molecular Weight | 426.717 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 493.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C30H50O | Melting Point | 178-183°C | |
| MSDS | Chinese USA | Flash Point | 218.6±21.0 °C | |
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β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.
Org. Lett. 16(13) , 3548-51, (2014) The effect of the steric volume at C-19 of (3S)-2,3-oxidosqualene 1 on the polycyclization reaction by β-amyrin synthase was examined. The substrate analogs, in which the methyl group at C-19 of 1 was substituted by an ethyl group and hydrogen atom, were conv... |
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Comparative analysis of CYP93E proteins for improved microbial synthesis of plant triterpenoids.
Phytochemistry 108 , 47-56, (2014) Cytochrome P450-dependent monooxygenases (P450s) belonging to the CYP93E subfamily catalyze the C-24 oxidation of the triterpene backbone during the biosynthesis of triterpenoid saponins, which are bioactive plant natural products. In our attempts to produce ... |
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Antitrypanosomal triterpenoid with an ε-lactone E-ring from Salvia urmiensis.
J. Nat. Prod. 76(9) , 1806-9, (2013) A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental an... |
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A non-michaelian behavior of the in vitro metabolism of the pentacyclic triterpene alfa and beta amyrins by employing rat liver microsomes.
J. Pharm. Biomed. Anal. 84 , 14-9, (2013) Pharmacological studies employing alpha and beta amyrin have demonstrated potential application in several biological activities suggesting their application as promising drugs. In the early drug development, metabolism studies may give important parameters r... |
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[Chemical constituents of Gentiana rhodantha].
Zhongguo Zhong Yao Za Zhi 38(3) , 362-5, (2013) To determine the chemical constituents of Gentiana rhodantha.To isolate the constituents, column chromatography over silica gel, MCI, Sephadex LH-20 and C18 reverse-phased silica gel were used. Spectroscopic methods were used to elucidate the structures of th... |
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Langmuir monolayer studies of the interaction of monoamphiphilic pentacyclic triterpenes with anionic mitochondrial and bacterial membrane phospholipids - searching for the most active terpene.
Biochim. Biophys. Acta 1838(10) , 2460-72, (2014) The interactions of three representative monoamphiphilic pentacyclic triterpenes (PTs) with cardiolipins (CL) and phosphatidylglycerols (PG) extracted from mitochondrial and bacterial membranes were comparatively characterized in binary Langmuir monolayers. T... |
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Anticancer activity of the roots of Ichnocarpus frutescens R. Br. and isolated triterpenes.
Pak. J. Pharm. Sci. 27(1) , 187-91, (2014) The roots of Ichnocarpus frutescens along with roots of Cissampelos pareira, Bauhinia vahlii and Ardisia solanacea are processed together and given orally to cure stomach cancer by the tribes of Chotanagpur and Santhal parganas of Bihar, India. In vitro antic... |
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Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem.
J. Diabetes 5(3) , 336-43, (2013) The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes.A methanolic extract and its chromatographic fractions (A1 -A6 ) were tes... |
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Potent microbial and tyrosinase inhibitors from stem bark of Bauhinia rufescens (Fabaceae).
Nat. Prod. Commun. 8(10) , 1435-7, (2013) The stem bark extracts of Bauhinia rufescens Lam. (Fabaceae) yielded 6-methoxy-7-methyl-8-hydroxydibenz[b,f]oxepin, alpha-amyrin acetate, beta-sitosterol 3-O-beta-D-xylopyranoside, 4-(2'-Hydroxyphenethyl)-5-methoxy-2-methylphenol, menisdaurin and sequoyitol. ... |
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Chemical constituents from the stem barks of Garcinia multiflora.
J. Asian Nat. Prod. Res. 15(11) , 1152-7, (2013) Investigation of the constituents from the stem barks of Garcinia multiflora has yielded two new compounds, multiflorabiphenyl A (1) and 24-p-E-coumaroyl-tetracosanyl (E)-ferulate (2), along with 10 known compounds, friedelin (3), friedelan-3β-ol (4), α,β-amy... |