Prostaglandin H2
Prostaglandin H2 structure
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Common Name | Prostaglandin H2 | ||
|---|---|---|---|---|
| CAS Number | 42935-17-1 | Molecular Weight | 352.465 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 490.1±40.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O5 | Melting Point | 42.8ºC | |
| MSDS | USA | Flash Point | 165.5±20.8 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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What we know about primary dysmenorrhea today: a critical review.
Hum. Reprod. Update 21 , 762-78, (2015) Primary dysmenorrhea, or painful menstruation in the absence of pelvic pathology, is a common, and often debilitating, gynecological condition that affects between 45 and 95% of menstruating women. Despite the high prevalence, dysmenorrhea is often poorly tre... |
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Anti-peptide antibodies against the human blood platelet thromboxane A2/prostaglandin H2 receptor. Production, purification and characterization.
Biochem. Pharmacol. 45(10) , 2071-8, (1993) Two anti-peptide antibodies have been raised against the human blood platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor. Based on the published sequence of the placental TXA2/PGH2 receptor, two decapeptide segments were selected as potential antige... |
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Evidence for coordinate, selective regulation of eicosanoid synthesis in platelet-derived growth factor-stimulated 3T3 fibroblasts and in HL-60 cells induced to differentiate into macrophages or neutrophils.
J. Biol. Chem. 263(36) , 19384-91, (1988) We used Swiss 3T3 fibroblasts stimulated with platelet-derived growth factor and HL-60 cells induced to differentiate into macrophages or neutrophils to study the regulation of prostaglandin and leukotriene synthesis. Addition of platelet-derived growth facto... |
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Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Thromb. Haemost. 87(1) , 114-21, (2002) Arachidonic acid (AA) is a potent inducer of platelet aggregation in vitro; this activity is due to its conversion to biologically active metabolites, prostaglandin (PG) endoperoxides and thromboxane A2 (TxA2). PG endoperoxides and TxA, are thought to act on ... |
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Levuglandins and isolevuglandins: stealthy toxins of oxidative injury.
Antioxid. Redox Signal. 7(1-2) , 185-201, (2005) Inspired by a reaction discovered through basic research on the chemistry of the bicyclic peroxide nucleus of the prostaglandin endoperoxide PGH2, we postulated that levulinaldehyde derivatives with prostaglandin side chains, levuglandins (LGs), and structura... |
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Pathophysiological role of thromboxane A2 and pharmacological approaches to its inhibition.
Z. Kardiol. 79 Suppl 3 , 151-4, (1990) The formation of the proischemic and prothrombotic thromboxane A2 (TXA2) and of its functional antagonist prostacyclin is increased in patients with unstable angina and myocardial infarction. Therefore, pharmacological interventions aim at an inhibition of th... |
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Localization of platelet prostaglandin production in the platelet dense tubular system.
Am. J. Pathol. 83(2) , 283-98, (1976) Platelet production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 8-(1-hydroxy-3-oxopropyl)-9, 12L-dihydroxy-5,10-heptadecadienoic acid (PHD), two metabolites of the prostaglandin cyclic endoperoxides PGG2 and PGH2, was found in this investigation to... |
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Prostaglandin H2 directly lowers human platelet cAMP levels.
Thromb. Res. 30(5) , 407-14, (1983) In the present study we investigated the ability of prostaglandin H2 (PGH2) to lower platelet cAMP levels independent of thromboxane A2 (TXA2) production. Human platelet-rich plasma was incubated (37 degrees C) with 13 nM prostacyclin (PGI2) to increase plate... |
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Cyclooxygenase-2 and thromboxane synthase in non-endocrine and endocrine tumors: a review.
Endocr. Pathol. 16(4) , 253-77, (2005) Prostaglandins (PG) are members of a large group of hormonally active fatty acids derived from free fatty acids. They are formed from arachidonic acid-the major PG precursor. Cyclooxygenase (COX)-1 and -2 are the rate-limiting steps in PG synthesis. COX-2 is ... |
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A Revised Mechanism for Human Cyclooxygenase-2.
J. Biol. Chem. 291 , 948-58, (2016) The mechanism of ω-6 polyunsaturated fatty acid oxidation by wild-type cyclooxygenase 2 and the Y334F variant, lacking a conserved hydrogen bond to the catalytic tyrosyl radical/tyrosine, was examined for the first time under physiologically relevant conditio... |