Mirtazapine
Mirtazapine structure
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Common Name | Mirtazapine | ||
|---|---|---|---|---|
| CAS Number | 61337-67-5 | Molecular Weight | 265.353 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 432.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H19N3 | Melting Point | 114-116ºC | |
| MSDS | N/A | Flash Point | 215.3±28.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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[Posttraumatic stress disorder].
Praxis (Bern 1994) 102(1) , 45-8, (2013)
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Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity?
J. Clin. Psychopharmacol. 33(1) , 99-103, (2013) Treatment with several psychopharmacological agents has been associated with increased leptin plasma concentrations. We measured leptin plasma concentrations in 76 adult depressed patients after a 6-day washout phase and again after 35 days of treatment with ... |
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Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
Elife 4 , (2015) Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that prece... |
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Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015) Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix compounds affect the ionization process of the target analyt... |
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Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.
Pharmacol. Rep. 64(6) , 1391-9, (2012) Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression.The present study aimed to examine the effect of treatment with fluoxetin... |
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Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice.
Pharmacol. Rep. 64(6) , 1567-72, (2012) Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve the positive, negative and some cognitive symptoms of schizophrenia.The present study was aimed at examining the effect of mirtaz... |
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Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients.
Biochem. Pharmacol. 93(1) , 104-9, (2015) A personalized treatment approach should be considered with the second-generation psychiatric drug mirtazapine because of high frequencies of side effects, including characteristic drowsiness. Plasma concentrations of mirtazapine in patients are influenced by... |
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A semi-automated method for the integrated evaluation of half-life and metabolic soft spots of discovery compounds.
Bioanalysis 4(14) , 1747-61, (2012) An integrated method that provides rates of both parent disappearance and metabolite formation was developed.Buspirone, mirtazapine and verapamil were used as model compounds in developing the method. Incubations were carried out on a robotic platform. Qualit... |
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Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.
S. D. Med. 67(4) , 137-9, (2014) We describe a rare case of severe drug-drug interaction between propafenone and mirtazapine leading to propafenone toxicity. A 69-year-old Caucasian male taking propafenone for atrial fibrillation was prescribed mirtazapine for insomnia. Subsequent to the fir... |
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Prokinetic effects of mirtazapine on gastrointestinal transit.
Am. J. Physiol. Gastrointest. Liver Physiol. 306(9) , G796-801, (2014) Mirtazapine is a noradrenergic and specific serotonergic antidepressant. The aim of this study was to investigate the effects of mirtazapine on gastrointestinal motility in dogs, including solid gastric emptying, antral and small intestinal contractions, and ... |