Pyocyanine
Pyocyanine structure
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Common Name | Pyocyanine | ||
|---|---|---|---|---|
| CAS Number | 85-66-5 | Molecular Weight | 210.231 | |
| Density | 1.24g/cm3 | Boiling Point | 403.3ºC at 760 mmHg | |
| Molecular Formula | C13H10N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 197.7ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.
PLoS ONE 10(4) , e0124961, (2015) Oxidative stress enhances inflammation and reduces the effectiveness of corticosteroids, but the inflammatory signalling pathways induced by oxidants remain ill-defined. Phosphorylation of histone 3 at serine 10 (H3-Pser10) marks out a subset of inflammatory ... |
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Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
PLoS Pathog. 11 , e1004946, (2015) Pseudomonas aeruginosa infection can be disastrous in chronic lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease. Its toxic effects are largely mediated by secreted virulence factors including pyocyanin, elastase and alkaline prot... |
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The impact of plant volatiles on bacterial quorum sensing.
Lett. Appl. Microbiol. 60(1) , 8-19, (2015) Studies describing the use of essential oil constituents as antimicrobial agents have steadily increased; however, some phyto-constituents are often overlooked due to unfavourable minimum inhibitory concentration (MIC) values. Virulence depends on transcripti... |
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Impact of glycerol-3-phosphate dehydrogenase on virulence factor production by Pseudomonas aeruginosa.
Can. J. Microbiol. 60(12) , 857-63, (2014) Pseudomonas aeruginosa establishes life-long chronic infections in the cystic fibrosis (CF) lung by utilizing various adaptation strategies. Some of these strategies include altering metabolic pathways to utilize readily available nutrients present in the hos... |
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Inhibition of NADPH oxidase-1 preserves beta cell function.
Diabetologia 58(1) , 113-21, (2014) Upregulation of the reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory cytokines and is concomitant with beta cell dysfunction. NOX-1 is a candidate mediator of inflammation-ind... |
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Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains.
Microbiology 161 , 1961-77, (2015) Pseudomonas aeruginosa causes chronic lung infections in people with cystic fibrosis (CF) and acute opportunistic infections in people without CF. Forty-two P. aeruginosa strains from a range of clinical and environmental sources were collated into a single r... |
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Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways.
PLoS Pathog. 11 , e1005133, (2015) Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. ... |
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New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing.
Antimicrob. Agents Chemother. 57(2) , 996-1005, (2013) The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still... |
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Pyocyanin stimulates quorum sensing-mediated tolerance to oxidative stress and increases persister cell populations in Acinetobacter baumannii.
Infect. Immun. 82(8) , 3417-25, (2014) Acinetobacter baumannii and Pseudomonas aeruginosa are nosocomial pathogens with overlapping sites of infection. This work reports that the two can coexist stably in mixed-culture biofilms. In a study intended to improve our understanding of the mechanism of ... |
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Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.
Pigment Cell Melanoma Res. 27(5) , 754-63, (2014) Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical contact. Rhododendrol competitively inhibited mushroom tyrosina... |