Alternariol
Alternariol structure
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Common Name | Alternariol | ||
|---|---|---|---|---|
| CAS Number | 641-38-3 | Molecular Weight | 258.226 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 586.9±39.0 °C at 760 mmHg | |
| Molecular Formula | C14H10O5 | Melting Point | 350°C (rough estimate) | |
| MSDS | Chinese USA | Flash Point | 232.3±20.6 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.
Toxicology 326 , 119-29, (2014) The mycotoxin alternariol (AOH), a frequent contaminant in fruit and grain, is known to induce cellular stress responses such as reactive oxygen production, DNA damage and cell cycle arrest. Cellular stress is often connected to autophagy, and we employed the... |
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AFLP variability, toxin production, and pathogenicity of Alternaria species from Argentinean tomato fruits and puree.
Int. J. Food Microbiol. 145(2-3) , 414-9, (2011) Large amounts of tomato fruits and derived products are produced in Argentina and may be contaminated by Alternaria toxins. Limited information is available on the genetic variability, toxigenicity, and pathogenicity of Alternaria strains occurring on tomato.... |
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Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice.
Toxicol. Lett. 214(1) , 46-52, (2012) Alternaria spp. are known to form a spectrum of secondary metabolites with alternariol (AOH), alternariol monomethyl ether (AME), altenuene (ALT) and tenuazonic acid (TA) as the major mycotoxins with respect to quantity. In the present study we investigated t... |
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Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata.
PLoS ONE 7(7) , e40564, (2012) Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins. Whereas the toxicology of these two polyketide-based compounds has been studied, nothing is known ab... |
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Effects of gamma radiation on the growth ofAlternaria alternataand on the production of alternariol and alternariol monomethyl ether in sunflower seeds
Food Microbiol. 26(8) , 927-31, (2009) The objective of the present study was to evaluate the effects of different gamma radiation doses on the growth of Alternaria alternata and on the production of toxins alternariol (AOH), and alternariol monomethyl ether (AME) in sunflower seed samples. After ... |
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Oxidative metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in precision-cut rat liver slices in vitro.
Mol. Nutr. Food. Res. 55(7) , 1079-86, (2011) Monohydroxylation of alternariol (AOH) and alternariol-9-methyl ether (AME) has previously been reported as a prominent metabolic route under cell-free conditions. This pathway gives rise to several catechol metabolites and may therefore be of toxicological r... |
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Heptaketides with antiviral activity from three endolichenic fungal strains Nigrospora sp., Alternaria sp. and Phialophora sp.
Fitoterapia 83(6) , 1087-91, (2012) Two new heptaketides, (+)-(2S,3S,4aS)-altenuene (1a) and (-)-(2S,3S,4aR)-isoaltenuene (2a), together with six known compounds, (-)-(2R,3R,4aR)-altenuene (1b), (+)-(2R,3R,4aS)-isoaltenuene (2b), 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (3), alternariol (4), a... |
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Mouse hepatoma cell lines differing in aryl hydrocarbon receptor-mediated signaling have different activities for glucuronidation.
Arch. Toxicol. 86(4) , 643-9, (2012) For studies on the aryl hydrocarbon receptor (AhR)-dependent toxicity of the mycotoxins alternariol (AOH) and alternariol methyl ether (AME), three mouse hepatoma (Hepa-1) cell lines with intact and with compromised AhR signaling were compared with respect to... |
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Influence of water activity and temperature on growth and mycotoxin production by Alternaria alternata on irradiated soya beans.
Int. J. Food Microbiol. 149(2) , 127-32, (2011) The aim of this study was to determine the effects of water activity (a(w)) (0.99-0.90), temperature (15, 25 and 30°C) and their interactions on growth and alternariol (AOH) and alternariol monomethyl ether (AME) production by Alternaria alternata on irradiat... |
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Impact of water activity and temperature on growth and alternariol and alternariol monomethyl ether production of Alternaria alternata isolated from soybean.
J. Food Prot. 73(2) , 336-43, (2010) The objective of this study was to determine the effect of water activity (a(w); 0.995, 0.98, 0.96, 0.94, 0.92, and 0.90), temperature (5, 18, 25, and 30 degrees C), incubation time (7 to 35 days), and their interactions on mycelial growth and alternariol (AO... |