ecgonidine methyl ester mesylate
ecgonidine methyl ester mesylate structure
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Common Name | ecgonidine methyl ester mesylate | ||
|---|---|---|---|---|
| CAS Number | 43021-26-7 | Molecular Weight | 181.23200 | |
| Density | 1.112g/cm3 | Boiling Point | 250.2ºC at 760 mmHg | |
| Molecular Formula | C10H15NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 96.9ºC | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
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Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine.
J. Anal. Toxicol. 33(8) , 447-55, (2009) Cocaine (COC) is a potent CNS stimulant that is metabolized to benzoylecgonine (BE) and further metabolized to minor metabolites such as m-hydroxybenzoylecgonine (m-HOBE). COC is also metabolized to norcocaine (NC). Cocaethylene (CE) is formed when cocaine an... |
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Detecting crack and other cocaine use with fastpatches.
Addict. Biol. 8(2) , 191-200, (2003) A continuing social problem is presented by the large number of individuals who use crack cocaine. Recent research has identified unique pyrolysis products of crack or burned cocaine as anhydroecgonine methylester (AEME) and ecgonidine (ECD) through gas chrom... |
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Artifact production in the assay of anhydroecgonine methyl ester in serum using gas chromatography-mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 792(2) , 345-51, (2003) The detection of the pyrolysis product anhydroecgonine methyl ester (AEME, methylecgonidine) after cocaine smoking using gas chromatography-mass spectrometry is hampered by the artifactual production of AEME. The amount of AEME increases with the amount of co... |
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Pharmacokinetics and pharmacodynamics of methylecgonidine, a crack cocaine pyrolyzate.
J. Pharmacol. Exp. Ther. 307(3) , 1179-87, (2003) Methylecgonidine is formed from cocaine base when smoked and has been identified in biological fluids of crack smokers. Ecgonidine, a metabolite of methylecgonidine formed via esterase activity, also has been identified in similar samples collected from crack... |
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Studies on in vitro degradation of anhydroecgonine methyl ester (methylecgonidine) in human plasma.
J. Anal. Toxicol. 26(8) , 567-70, (2002) The presence of the cocaine pyrolysis product anhydroecgonine methyl ester (AEME, methylecgonidine) in plasma indicates the smoking of cocaine. The stability of this analyte in human plasma has not been studied. In the present investigation AEME and its hydro... |
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Evidence for cocaine and methylecgonidine stimulation of M(2) muscarinic receptors in cultured human embryonic lung cells.
Br. J. Pharmacol. 132(2) , 451-60, (2001) 1. Muscarinic cholinoceptor stimulation leads to an increase in guanylyl cyclase activity and to a decrease in adenylyl cyclase activity. This study examined the effects of cocaine and methylecgonidine (MEG) on muscarinic receptors by measurement of cyclic GM... |
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Enhancement of nitric oxide production by methylecgonidine in cultured neonatal rat cardiomyocytes.
Br. J. Pharmacol. 135(1) , 188-96, (2002) 1. In the present experiments, we investigated the effects of methylecgonidine (MEG) on nitric oxide (NO) production in cultured neonatal rat cardiomyocytes. Incubation of cultured cardiomyocytes with carbachol or MEG for 48 h significantly enhanced NO produc... |
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Identification of anhydroecgonine ethyl ester in the urine of a drug overdose victim.
J. Forensic Sci. 50(6) , 1481-5, (2005) Toxicological evaluation of postmortem urine collected from a 41-year-old deceased white male detected anhydroecgonine ethyl ester (ethylecgonidine, AEEE), a transesterification product of smoked cocaine co-abused with ethanol. A solid phase extraction (SPE) ... |
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A fatally mistaken fruit juice drink: an unordinary way of cocaine intoxication.
J. Forensic Leg. Med. 17(8) , 434-6, (2010) Cocaine is one of the drugs of abuse more frequently consumed in Spain. Furthermore, Spain due to its geographical position is used by trafficker's organizations as the port of entrance of cocaine in the European Union. We present here a case of a fatal intox... |
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Detection of smoked cocaine marker (anhydroecgonine methylester) in nails.
J. Anal. Toxicol. 29(7) , 765-8, (2005)
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