Chromomycin A3
Chromomycin A3 structure
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Common Name | Chromomycin A3 | ||
|---|---|---|---|---|
| CAS Number | 7059-24-7 | Molecular Weight | 1183.25000 | |
| Density | 1.43g/cm3 | Boiling Point | 1147.6ºC at 760 mmHg | |
| Molecular Formula | C57H82O26 | Melting Point | 185℃ | |
| MSDS | Chinese USA | Flash Point | 311.1ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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High diversity in CMA3/DAPI-banding patterns in Heteropterans.
Cytogenet. Genome Res. 142(1) , 46-53, (2014) Heteroptera is the most numerous and diverse suborder of Hemiptera, with about 38,000 species. This diversity also involves cytogenetic features, including chromosome number and a sex determining system. Information about heterochromatin occurrence and distri... |
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Association of aureolic acid antibiotic, chromomycin A3 with Cu2+ and its negative effect upon DNA binding property of the antibiotic.
Biometals 25(2) , 435-50, (2012) Here we have examined the association of an aureolic acid antibiotic, chromomycin A3 (CHR), with Cu(2+). CHR forms a high affinity 2:1 (CHR:Cu(2+)) complex with dissociation constant of 0.08 × 10(-10) M(2) at 25°C, pH 8.0. The affinity of CHR for Cu(2+) is hi... |
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Evaluation of sperm's chromatin quality with acridine orange test, chromomycin A3 and aniline blue staining in couples with unexplained recurrent abortion.
J. Assist. Reprod. Genet. 26(11-12) , 591-6, (2009) To evaluate the sperm's chromatin quality in couples with spontaneous recurrent abortion.Thirty couples with spontaneous recurrent abortion (case group) and 30 fertile couples (control group) referring to Zeinabieh Gynecology clinic of Shiraz were included. S... |
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Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships.
Biochem. Pharmacol. 79(10) , 1418-27, (2010) Differential cleavage at three restriction enzyme sites was used to determine the specific binding to DNA of the antitumour antibiotics mithramycin A (MTA), chromomycin A(3) (CRO) and six chromophore-modified analogues bearing shorter side chains attached at ... |
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Evaluation of ubiquitin and annexin V in sperm population selected based on density gradient centrifugation and zeta potential (DGC-Zeta).
J. Assist. Reprod. Genet. 29(4) , 365-71, (2012) Sperm that bypass natural apoptosis and the ubiquitin-proteasome system may find their way into semen. In order to avoid the insemination of such sperm during an intracytoplasmic sperm injection (ICSI) treatment, novel sperm selection procedures such as the Z... |
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The impact of spermine competition on the efficacy of DNA-binding Fe(II), Co(II), and Cu(II) complexes of dimeric chromomycin A3
J. Inorg. Biochem. 103(12) , 1626-33, (2009) Chromomycin (Chro) forms a 2:1 drug/metal complex through the chelation with Fe(II), Co(II), or Cu(II) ion. The effects of spermine on the interaction of Fe(II), Co(II), and Cu(II) complexes of dimeric Chro with DNA were studied. Circular dichroism (CD) measu... |
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The binding of the Co(II) complex of dimeric chromomycin A3 to GC sites with flanking G:G mismatches.
J. Inorg. Biochem. 121 , 28-36, (2013) Some neurological diseases are correlated with expansion of (CXG)n trinucleotide repeats, which contain many contiguous GpC flanked by mismatched X/X base pair. This study focused on the binding of the Co(II) complex of dimeric chromomycin A3(Chro), Co(II)(Ch... |
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Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.
Biochemistry 50(8) , 1421-8, (2011) Inactivation and initial interrogation of key oxygenase CmmOIV of the biosynthetic pathway of chromomycin A(3) in Streptomyces griseus ssp. griseus revealed that a completely methylated and acetylated prechromomycin is the preferred substrate of this enzyme. ... |
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CASA derived human sperm abnormalities: correlation with chromatin packing and DNA fragmentation.
J. Assist. Reprod. Genet. 29(12) , 1327-34, (2012) The present study was undertaken to evaluate the effects of morphokinetic abnormalities of human spermatozoa on chromatin packing and DNA integrity and possible beneficial effects of sperm selection in ICSI.Semen samples from 1002 patients were analysed for m... |
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Lipase-catalyzed preparation of chromomycin A₃ analogues and biological evaluation for anticancer activity.
Bioorg. Med. Chem. Lett. 22(13) , 4310-3, (2012) Several acyl derivatives of the aureolic acid chromomycin A(3) were obtained via lipase-catalyzed acylation. Lipase B from Candida antarctica (CAL-B) was found to be the only active biocatalyst, directing the acylation regioselectively towards the terminal se... |