Fosinopril sodium
Fosinopril sodium structure
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Common Name | Fosinopril sodium | ||
|---|---|---|---|---|
| CAS Number | 88889-14-9 | Molecular Weight | 563.662 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 705.7±70.0 °C at 760 mmHg | |
| Molecular Formula | C30H45NNaO7P | Melting Point | 196-198ºC | |
| MSDS | Chinese USA | Flash Point | 380.6±35.7 °C | |
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects... |
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Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Pharmacol. Res. 65(3) , 285-96, (2012) The renin-angiotensin system (RAS) exists in the brain and it may be involved in pathogenesis of neurological and psychiatric disorders including seizures. The aim of the present research was to evaluate the effects of some angiotensin-converting enzyme inhib... |
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Meta-analysis of randomized controlled trials on effect of angiotensin-converting enzyme inhibitors on cancer risk.
Am. J. Cardiol. 108(2) , 294-301, (2011) The renin-angiotensin system is an important mediator of tumor progression and metastasis. A recent meta-analysis of randomized controlled trials reported an increased risk of cancer with angiotensin receptor blockers. It is unknown whether angiotensin-conver... |
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A stewardship intervention program for safe medication management and use of antidiabetic drugs.
Clin. Interv. Aging 10 , 1201-12, (2015) Diabetes patients are complex due to considerations of polypharmacy, multimorbidities, medication adherence, dietary habits, health literacy, socioeconomic status, and cultural factors. Meanwhile, insulin and oral hypoglycemic agents are high-alert medication... |
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Prostaglandin E1 for preventing the progression of diabetic kidney disease.
Cochrane Database Syst. Rev. (5) , CD006872, (2010) Diabetic kidney disease (DKD) is one of the major chronic microvascular complications in diabetes mellitus, and may progress to end-stage kidney disease (ESKD). There are no definitely effective approaches for preventing, delaying or treating DKD. Small studi... |
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Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax.
J. Radiat. Res. 53(1) , 10-7, (2012) Our long-term goal is to use angiotensin converting enzyme (ACE) inhibitors to mitigate the increase in lung collagen synthesis that is induced by irradiation to the lung, which could result from accidental exposure or radiological terrorism. Rats (WAG/RijCmc... |
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Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease.
J. Pharm. Biomed. Anal. 60 , 32-43, (2012) The pathological development of diabetic kidney disease (DKD) might involve metabolic perturbations in kidney tissue. The present study was designed to detect the systematic alterations of renal cortex metabolites thereby exploring the related mechanisms of D... |
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A randomized controlled trial of angiotensin-converting enzyme inhibition for skeletal muscle dysfunction in COPD.
Chest 146(4) , 932-40, (2014) Skeletal muscle impairment is a recognized complication of COPD, predicting mortality in severe disease. Increasing evidence implicates the renin-angiotensin system in control of muscle phenotype. We hypothesized that angiotensin-converting enzyme (ACE) inhib... |
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Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile.
J. Nutr. Health Aging 14(6) , 457-60, (2010) The present study evaluates the effects of a 6-month treatment with an ACE-inhibitor (ie, fosinopril) on serum concentrations of total IGF-1 and IGF binding protein (IGFBP)-3 in older adults at high risk for cardiovascular disease.Data are from the Trial of A... |
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Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats.
Kidney Blood Press. Res. 34(5) , 350-7, (2011) Klotho, a newly identified antiaging gene, predominantly detected in the kidney, has pleiotropic protective effects on kidney diseases. Several studies have confirmed the association between Klotho and oxidative stress. The present studies were performed to e... |