Fosinopril sodium
Modify Date: 2024-01-02 20:04:37
Fosinopril sodium structure
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Common Name | Fosinopril sodium | ||
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| CAS Number | 88889-14-9 | Molecular Weight | 563.662 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 705.7±70.0 °C at 760 mmHg | |
| Molecular Formula | C30H45NNaO7P | Melting Point | 196-198ºC | |
| MSDS | Chinese USA | Flash Point | 380.6±35.7 °C | |
Use of Fosinopril sodiumFosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy [1-3]. |
| Name | fosinopril sodium |
|---|---|
| Synonym | More Synonyms |
| Description | Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy [1-3]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 705.7±70.0 °C at 760 mmHg |
| Melting Point | 196-198ºC |
| Molecular Formula | C30H45NNaO7P |
| Molecular Weight | 563.662 |
| Flash Point | 380.6±35.7 °C |
| Exact Mass | 563.301208 |
| PSA | 122.85000 |
| LogP | 6.09 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.532 |
| Storage condition | -20°C Freezer |
| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a... |
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Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Pharmacol. Res. 65(3) , 285-96, (2012) The renin-angiotensin system (RAS) exists in the brain and it may be involved in pathogenesis of neurological and psychiatric disorders including seizures. The aim of the present research was to evalu... |
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Meta-analysis of randomized controlled trials on effect of angiotensin-converting enzyme inhibitors on cancer risk.
Am. J. Cardiol. 108(2) , 294-301, (2011) The renin-angiotensin system is an important mediator of tumor progression and metastasis. A recent meta-analysis of randomized controlled trials reported an increased risk of cancer with angiotensin ... |
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- Shanghai Jizhi Biochemical Technology Co., Ltd
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- Product Name: Fosinopril sodium
- Price: ￥1918.0/500mg ￥908.0/100mg ￥338.0/25mg
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- China
- Product Name: Fosinopril sodium
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- Purity: 98.0%
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- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Fosinopril sodium
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
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