Fosinopril sodium
Fosinopril sodium structure
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Common Name | Fosinopril sodium | ||
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| CAS Number | 88889-14-9 | Molecular Weight | 563.662 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 705.7±70.0 °C at 760 mmHg | |
| Molecular Formula | C30H45NNaO7P | Melting Point | 196-198ºC | |
| MSDS | Chinese USA | Flash Point | 380.6±35.7 °C | |
Use of Fosinopril sodiumFosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy [1-3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | fosinopril sodium |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.Target: ACEFosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy [1-3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 705.7±70.0 °C at 760 mmHg |
| Melting Point | 196-198ºC |
| Molecular Formula | C30H45NNaO7P |
| Molecular Weight | 563.662 |
| Flash Point | 380.6±35.7 °C |
| Exact Mass | 563.301208 |
| PSA | 122.85000 |
| LogP | 6.09 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.532 |
| InChIKey | TVTJZMHAIQQZTL-UHBAQTEVSA-M |
| SMILES | CCC(=O)OC(OP(=O)(CCCCc1ccccc1)CC(=O)N1CC(C2CCCCC2)CC1C(=O)[O-])C(C)C.[Na+] |
| Storage condition | -20°C Freezer |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a... |
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Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Pharmacol. Res. 65(3) , 285-96, (2012) The renin-angiotensin system (RAS) exists in the brain and it may be involved in pathogenesis of neurological and psychiatric disorders including seizures. The aim of the present research was to evalu... |
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Meta-analysis of randomized controlled trials on effect of angiotensin-converting enzyme inhibitors on cancer risk.
Am. J. Cardiol. 108(2) , 294-301, (2011) The renin-angiotensin system is an important mediator of tumor progression and metastasis. A recent meta-analysis of randomized controlled trials reported an increased risk of cancer with angiotensin ... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Tensozide |
| Dynacil |
| Fosinopril sodium |
| (4S)-4-Cyclohexyl-1-{[(R)-[(1R)-2-methyl-1-(propionyloxy)propoxy](4-phenylbutyl)phosphoryl]acetyl}-L-proline |
| Fosinorm |
| Staril |
| sodium,(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate |
| (4S)-4-cyclohexyl-1-{[(R)-{[(1R)-2-methyl-1-(propanoyloxy)propyl]oxy}(4-phenylbutyl)phosphoryl]acetyl}-L-proline |
| MFCD00897699 |
| Fositen |
| Fozitec |
| Elidur |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of fosinopril sodium? |
| A: Molecular formula of fosinopril sodium is C30H45NNaO7P. |
| Q: What English synonyms does fosinopril sodium have? |
| A: English synonyms of fosinopril sodium: Tensozide, Dynacil, Fosinopril sodium, (4S)-4-Cyclohexyl-1-{[(R)-[(1R)-2-methyl-1-(propionyloxy)propoxy](4-phenylbutyl)phosphoryl]acetyl}-L-proline, Fosinorm, Staril, sodium,(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate, (4S)-4-cyclohexyl-1-{[(R)-{[(1R)-2-methyl-1-(propanoyloxy)propyl]oxy}(4-phenylbutyl)phosphoryl]acetyl}-L-proline, MFCD00897699, Fositen, Fozitec, Elidur. |
| Q: What is the polar surface area (PSA) of fosinopril sodium? |
| A: Polar surface area (PSA) of fosinopril sodium is 122.85000. |
| Q: What is the boiling point of fosinopril sodium? |
| A: Boiling point of fosinopril sodium is 705.7±70.0 °C at 760 mmHg. |
| Q: What is the InChIKey of fosinopril sodium? |
| A: InChIKey of fosinopril sodium is TVTJZMHAIQQZTL-UHBAQTEVSA-M. |
| Q: What is the molecular weight of fosinopril sodium? |
| A: Molecular weight of fosinopril sodium is 563.662. |
| Q: What is the melting point of fosinopril sodium? |
| A: Melting point of fosinopril sodium is 196-198ºC. |
| Q: What is the LogP of fosinopril sodium? |
| A: LogP of fosinopril sodium is 6.09. |
| Q: What is the SMILES notation of fosinopril sodium? |
| A: SMILES notation of fosinopril sodium is CCC(=O)OC(OP(=O)(CCCCc1ccccc1)CC(=O)N1CC(C2CCCCC2)CC1C(=O)[O-])C(C)C.[Na+]. |
| Q: What are the storage conditions for fosinopril sodium? |
| A: Storage conditions for fosinopril sodium: -20°C Freezer. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |