Salsalate
Salsalate structure
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Common Name | Salsalate | ||
|---|---|---|---|---|
| CAS Number | 552-94-3 | Molecular Weight | 258.226 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 482.9±25.0 °C at 760 mmHg | |
| Molecular Formula | C14H10O5 | Melting Point | 139-151 °C | |
| MSDS | Chinese USA | Flash Point | 188.0±16.7 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.
J. Pharm. Biomed. Anal. 111 , 333-43, (2015) Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both analytically and on a preparative scale. The use of SFC as a... |
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Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.
Br. J. Pharmacol. 172 , 5293-305, (2016) Salsalate (salicylsalicylic acid) is an anti-inflammatory drug that was recently found to exert beneficial metabolic effects on glucose and lipid metabolism. Although its utility in the prevention and management of a wide range of vascular disorders, includin... |
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Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.
J. Pharmacol. Exp. Ther. 339(3) , 896-904, (2011) Type 2 diabetes mellitus (T2DM) arises owing to insulin resistance and β-cell dysfunction. Chronic inflammation is widely identified as a cause of T2DM. The Goto-Kakizaki (GK) rat is a spontaneous rodent model for T2DM with chronic inflammation. The purpose o... |
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Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.
Diabetes 61(4) , 790-6, (2012) Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in adipose tissue is increased in vitro b... |
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Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans.
Diabetes Care 34(7) , 1634-8, (2011) Insulin recruits muscle microvasculature, thereby increasing endothelial exchange surface area. Free fatty acids (FFAs) cause insulin resistance by activating inhibitor of κB kinase β. Elevating plasma FFAs impairs insulin's microvascular and metabolic action... |
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Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.
AIDS 24(12) , 1958-61, (2010) In this 13-week, open-label, randomized study of the anti-inflammatory salsalate versus usual care, there were no significant improvements in flow-mediated dilation of the brachial artery, endothelial activation, inflammation or coagulation markers, homeostas... |
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Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes.
Clin. Transl. Sci. 1(1) , 36-43, (2008) Chronic subacute inflammation is implicated in the pathogenesis of insulin resistance and type 2 diabetes. Salicylates were shown years ago to lower glucose and more recently to inhibit NF-kappaB activity. Salsalate, a prodrug form of salicylate, has seen ext... |
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Gastroduodenal mucosal damage with salsalate versus aspirin: results of experimental models and endoscopic studies in humans.
Semin. Arthritis Rheum. 20(2) , 121-7, (1990) Animal models have identified multiple mechanisms of aspirin toxicity. Aspirin inhibits cyclooxygenase in the gastroduodenal mucosa leading to a decrease in endogenous prostaglandins. Prostaglandin mediated mucus and bicarbonate secretion, epithelial hydropho... |
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Potential role of salicylates in type 2 diabetes.
Ann. Pharmacother. 44(7-8) , 1207-21, (2010) To review the evidence base supporting the use of salicylates for glucose level control in patients with type 2 diabetes and provide a comprehensive review of available information describing the potential role of salicylates and, in particular, salsalate, fo... |
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Development of a disposable amperometric biosensor for salicylate based on a plastic electrochemical microcell.
Biosens. Bioelectron. 25(10) , 2200-4, (2010) The use of an amperometric biosensor for rapid salicylate determination in blood is described. Photolitography was used to make gold electrodes on a polyester film. The plastic microcell was characterized using cyclic voltammetry to demonstrate the electroche... |