Picrotoxinin
Picrotoxinin structure
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Common Name | Picrotoxinin | ||
|---|---|---|---|---|
| CAS Number | 17617-45-7 | Molecular Weight | 292.28400 | |
| Density | 1.52g/cm3 | Boiling Point | 551.6ºC at 760mmHg | |
| Molecular Formula | C15H16O6 | Melting Point | 203-205ºC | |
| MSDS | Chinese USA | Flash Point | 214ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.
J. Physiol. 581(Pt 3) , 1001-18, (2007) The onset of motor learning in rats coincides with exclusive expression of GABAA receptors containing alpha6 and delta subunits in the granule neurons of the cerebellum. This development temporally correlates with the presence of a spontaneously active chlori... |
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Cys-Loop Receptor Channel Blockers Also Block GLIC
Biophys. J. 101(12) , 2912-8, (2011) The Gloeobacter ligand-gated ion channel (GLIC) is a bacterial homolog of vertebrate Cys-loop ligand-gated ion channels. Its pore-lining region in particular has a high sequence homology to these related proteins. Here we use electrophysiology to examine a ra... |
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Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration.
J. Neurosci. 33(24) , 10165-81, (2013) Amyloid precursor protein (APP) belongs to a family of evolutionarily conserved transmembrane glycoproteins that has been proposed to regulate multiple aspects of cell motility in the nervous system. Although APP is best known as the source of β-amyloid fragm... |
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The human taste receptor hTAS2R14 responds to a variety of different bitter compounds.
Biochem. Biophys. Res. Commun. 319(2) , 479-85, (2004) The recent advances in the functional expression of TAS2Rs in heterologous systems resulted in the identification of bitter tastants that specifically activate receptors of this family. All bitter taste receptors reported to date exhibit a pronounced selectiv... |
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Inner and outer retinal mechanisms engaged by epiretinal stimulation in normal and rd mice.
Vis. Neurosci. 28(2) , 145-54, (2011) Retinal prosthetic devices are being developed to bypass degenerated retinal photoreceptors by directly activating retinal neurons with electrical stimulation. However, the retinal circuitry that is activated by epiretinal stimulation is not well characterize... |
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Role of a serine residue (S278) in the pore-facing region of the housefly L-glutamate-gated chloride channel in determining sensitivity to noncompetitive antagonists.
Insect Mol. Biol. 17(4) , 341-50, (2008) Gamma-hexachlorocyclohexane (gamma-HCH), fipronil and picrotoxinin are noncompetitive antagonists (NCAs) of L-glutamate-gated chloride channels (GluCls), yet their potencies are weaker than those on gamma-aminobutyric acid receptors (GABARs). The A302S mutati... |
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RdlDv, a novel GABA-gated chloride channel gene from the American dog tick Dermacentor variabilis.
Insect Biochem. Mol. Biol. 33(6) , 595-9, (2003) The American dog tick Dermacentor variabilis is a major transmitter of bacterial and viral pathogens in human and animal populations, and compounds active against this species would benefit both human and animal health. Invertebrate GABA-gated chloride channe... |
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Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms.
J. Neurophysiol. 86(1) , 75-85, (2001) The subthalamic nucleus (STN) influences the output of the basal ganglia, thereby interfering with motor behavior. The main inputs to the STN are GABAergic. We characterized the GABA(A) receptors expressed in the STN and investigated the response of subthalam... |
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Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.
Mol. Pharmacol. 77(4) , 539-46, (2010) The rho 1 GABA receptor is inhibited by a number of neuroactive steroids. A previous study (J Pharmacol Exp Ther 323:236-247, 2007) focusing on the electrophysiological effects of inhibitory steroids on the rho 1 receptor found that steroid inhibitors could b... |
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Investigation of structural requirements for inhibitory activity at the rat and housefly picrotoxinin binding sites in ionotropic GABA receptors using DISCOtech and CoMFA.
Chemosphere 69(6) , 864-71, (2007) A number of widely diverse compounds that show inhibitory activities at the picrotoxinin binding sites in housefly and rat GABA receptors were investigated by using the distance comparison technique (DISCOtech) and comparative molecular field analysis (CoMFA)... |