4,4'-Diphenylmethane diisocyanate
4,4'-Diphenylmethane diisocyanate structure
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Common Name | 4,4'-Diphenylmethane diisocyanate | ||
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| CAS Number | 101-68-8 | Molecular Weight | 250.252 | |
| Density | 1.19 | Boiling Point | 392 ºC | |
| Molecular Formula | C15H10N2O2 | Melting Point | 38-44 °C | |
| MSDS | Chinese USA | Flash Point | 196 ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Role of dermal exposure in systemic intake of methylenediphenyl diisocyanate (MDI) among construction and boat building workers.
Toxicol. Lett. 232(3) , 595-600, (2015) The causal relationship between inhalation exposure to methylenediphenyl diisocyanate (MDI) and the risk of occupational asthma is well known, but the role of dermal exposure and dermal uptake of MDI in this process is still unclear. The aims of this study we... |
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Development of sandwich ELISAs for the detection of aromatic diisocyanate adducts
J. Immunol. Methods 397(1-2) , 66-70, (2013) Diisocyanates (dNCOs) are highly reactive low molecular weight chemicals commonly used in the manufacturing industry. Occupational exposures to dNCOs have been shown to elicit allergic sensitization and occupational asthma. Among the most commonly used dNCOs ... |
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Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.
Toxicol. Sci. 129(1) , 166-73, (2012) Diisocyanates are a common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes, glutathione S-transferases (GSTM1, GSTT1, GSTM3, GSTP1), m... |
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Occupational contact allergy to monomeric isocyanates.
Contact Dermatitis 67(2) , 78-88, (2012) The monomeric isocyanates diphenylmethane diisocyanate (MDI), 2,4-toluene diisocyanate (TDI), isophorone diisocyanate (IPDI) and 1,6-hexamethylene diisocyanate (HDI) are used in polyurethane products and sometimes cause contact allergy.To describe patients wi... |
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Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopathology following dermal exposure of male rats to TDI.
Toxicol. Lett. 199(3) , 364-71, (2010) Polyurethanes (PU) are polymers made with diisocyanates such as MDI (4,4'-methylene diphenyl diisocyanate) and TDI (2,4-toluene diisocyanate and 2,6-toluene diisocyanate). Investigations have been undertaken with MDI and TDI to assess dermal uptake and result... |
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Synthetic approaches to obtain amino acid adducts of 4,4'-methylenediphenyl diisocyanate.
Chem. Res. Toxicol. 25(12) , 2704-14, (2012) 4,4'-Methylenediphenyl diisocyanate (MDI) is the most important isocyanate used in the chemical industry. Lung sensitization and asthma are the main types of damage after exposure to MDI. Albumin adducts of MDI might be involved in the etiology of sensitizati... |
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Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4′-methylenediphenyl diisocyanate (MDI)
Mutat. Res. 723(1) , 1-10, (2011) Toluene diisocyanate (TDI) and 4,4′-methylenediphenyl diisocyanate (MDI), used in the production of polyurethane foam, are well known for their irritating and sensitizing properties. Contradictory results have been obtained on their genotoxicity. We investiga... |
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Isocyanate and total inhalable particulate air measurements in the European wood panel industry.
Int. J. Hyg. Environ. Health 213(6) , 475-88, (2010) It is well known that the use of MDI (methylene diphenyldiisocyanate) as an alternative for formaldehyde-based resins is seen as a responsible option to reduce formaldehyde emissions for CWP (Composite Wood Products) in buildings. However, there are concerns ... |
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Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate.
Mol. Immunol. 54(2) , 233-7, (2013) Methylene diphenyl diisocyanate (MDI), a low molecular weight chemical important for producing polyurethane foam, coatings, and elastomers is a major cause of occupational asthma, however, mechanisms of disease pathogenesis remain poorly understood. This stud... |
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Occupational asthma related to low levels of airborne methylene diphenyl diisocyanate (MDI) in orthopedic casting work.
Am. J. Ind. Med. 54(12) , 906-10, (2011) Orthopedic plaster casts contain methylene diphenyl diisocyanate (MDI). A few case reports have suggested occupational asthma to MDI in casting work. However, the knowledge of the exposure levels related to the occupational asthma cases is lacking. We report ... |