3-Quinuclidinyl benzilate
3-Quinuclidinyl benzilate structure
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Common Name | 3-Quinuclidinyl benzilate | ||
|---|---|---|---|---|
| CAS Number | 6581-06-2 | Molecular Weight | 337.41200 | |
| Density | 1.25g/cm3 | Boiling Point | 439ºC at 760 mmHg | |
| Molecular Formula | C21H23NO3 | Melting Point | 164ºC | |
| MSDS | Chinese USA | Flash Point | 219.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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The effect of oxime reactivators on muscarinic receptors: functional and binding examinations.
Environ. Toxicol. Pharmacol. 31(3) , 364-70, (2011) The antidotal treatment of organophosphorus poisoning is still a problematic issue since no versatile antidote has been developed yet. In our study, we focused on an interesting property, which does not relate to the reactivation of inhibited acetylcholineste... |
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Comparison of subcellular distribution and functions between exogenous and endogenous M1 muscarinic acetylcholine receptors.
Life Sci. 93(1) , 17-23, (2013) Recombinant systems have been used for evaluating the properties of G-protein-coupled receptors (GPCRs) on the assumption of cell surface expression. However, many GPCRs, including muscarinic acetylcholine receptors (mAChRs), have also been reported to be dis... |
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Assessment of novel muscarinic acetylcholine receptors in rat cerebral cortex by a tissue segment binding method.
J. Pharmacol. Sci. 112(4) , 444-51, (2010) Muscarinic acetylcholine receptors (mAChRs) of rat cerebral cortex were evaluated using a tissue segment radioligand binding assay. [(3)H]-Quinuclidinyl benzilate (QNB, a hydrophobic ligand) specifically bound to mAChRs in the cortex segments. The total mAChR... |
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Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor.
Biochemistry 51(22) , 4518-40, (2012) At least four allosteric sites have been found to mediate the dose-dependent effects of gallamine on the binding of [(3)H]quinuclidinylbenzilate (QNB) and N-[(3)H]methylscopolamine (NMS) to M(2) muscarinic receptors in membranes and solubilized preparations f... |
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Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells.
J. Neurochem. 118(6) , 958-67, (2011) Signaling by muscarinic agonists is thought to result from the activation of cell surface acetylcholine receptors (mAChRs) that transmit extracellular signals to intracellular systems. In N1E-115 neuroblastoma cells, we detected both plasma membrane and intra... |
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Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.
Biol. Psychiatry 35(4) , 855-69, (2010) We recently identified LY2033298 as a novel allosteric potentiator of acetylcholine (ACh) at the M(4) muscarinic acetylcholine receptor (mAChR). This study characterized the molecular mode of action of this modulator in both recombinant and native systems. Ra... |
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Neurotoxicity of anhydroecgonine methyl ester, a crack cocaine pyrolysis product.
Toxicol. Sci. 128(1) , 223-34, (2012) Smoking crack cocaine involves the inhalation of cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). Although there is evidence that cocaine is neurotoxic, the neurotoxicity of AEME has never been evaluated. AEME seems to have cholinergic ... |
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Serum anticholinergic activity and postoperative cognitive dysfunction in elderly patients.
Anesth. Analg. 119(4) , 947-55, (2014) Cerebral cholinergic transmission plays a key role in cognitive function, and anticholinergic drugs administered during the perioperative phase are a hypothetical cause of postoperative cognitive dysfunction (POCD). We hypothesized that a perioperative increa... |
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Acetylcholine-induced neuronal differentiation: muscarinic receptor activation regulates EGR-1 and REST expression in neuroblastoma cells.
J. Neurochem. 108(3) , 821-34, (2009) Neurotransmitters are considered part of the signaling system active in nervous system development and we have previously reported that acetylcholine (ACh) is capable of enhancing neuronal differentiation in cultures of sensory neurons and N18TG2 neuroblastom... |
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Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques.
Drug Test. Anal. 2(9) , 430-5, (2010) Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression (GA-PLS), and principal components-artificial neural network (PC-ANN) analysis were investigated for their application... |