diethyl 4-aminobenzylphosphonate

diethyl 4-aminobenzylphosphonate Structure
diethyl 4-aminobenzylphosphonate structure
Common Name diethyl 4-aminobenzylphosphonate
CAS Number 20074-79-7 Molecular Weight 243.23900
Density 1.153g/cm3 Boiling Point 383.3ºC at 760mmHg
Molecular Formula C11H18NO3P Melting Point 90-94 °C(lit.)
MSDS USA Flash Point 185.6ºC

Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin.

Bioorg. Med. Chem. Lett. 21 , 5098-101, (2011)

Autotaxin (ATX) is an attractive target for the anticancer therapeutics that inhibits angiogenesis, invasion and migration. ATX is an extracellular lysophospholipase D that hydrolyzes lysophosphatidylcholine to form the bioactive lipid lysophosphatidic acid. ...