Etomidate
Etomidate structure
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Common Name | Etomidate | ||
|---|---|---|---|---|
| CAS Number | 33125-97-2 | Molecular Weight | 244.289 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 391.5±17.0 °C at 760 mmHg | |
| Molecular Formula | C14H16N2O2 | Melting Point | 72-74ºC | |
| MSDS | Chinese USA | Flash Point | 190.6±20.9 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Comparison of the effects of four anaesthetics on haematological and blood biochemical profiles in pikeperch (Sander lucioperca L.).
Neuro Endocrinol. Lett. 33 Suppl 3 , 66-71, (2012) The objectives of the study were to compare the effects of Propiscin, 2-phenoxyethanol, clove oil and tricaine methane sulphonate (MS 222), anaesthetics frequently used in aquaculture.The haematological and biochemical blood profiles of pikeperch (Sander luci... |
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Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice.
Infect. Immun. 83(2) , 780-91, (2015) Mycobacterium abscessus is a pathogenic, rapidly growing mycobacterium involved in pulmonary and cutaneo-mucous infections worldwide, to which cystic fibrosis patients are exquisitely susceptible. The analysis of the genome sequence of M. abscessus showed tha... |
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Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.
Anesthesiology 121(2) , 290-301, (2014) R-etomidate possesses unique desirable properties but potently suppresses adrenocortical function. Consequently, efforts are being made to define structure-activity relationships with the goal of designing analogues with reduced adrenocortical toxicity. The a... |
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Tonic current through GABAA receptors and hyperpolarization-activated cyclic nucleotide-gated channels modulate resonance properties of rat subicular pyramidal neurons.
Eur. J. Neurosci. 40(1) , 2241-54, (2014) The subiculum, considered to be the output structure of the hippocampus, modulates information flow from the hippocampus to various cortical and sub-cortical areas such as the nucleus accumbens, lateral septal region, thalamus, nucleus gelatinosus, medial nuc... |
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Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement Pathways.
Circ. Res. 117 , 279-88, (2015) Reduction of myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of ischemia/reperfusion in an organ remote from the heart before sustained myocardial ischemia/reperfusion, was confirmed in all species so far, including humans.T... |
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High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.
Assay Drug Dev. Technol. 12(1) , 55-79, (2014) The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is hyperactivated in most cancers and represents a plausible therapeutic target. In the absence of STAT3-selective small-molecule inhibitors, we sought to develop pS... |
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Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia.
J. Cereb. Blood Flow Metab. 35(2) , 292-303, (2015) Ischemic stroke not only impairs neuronal function but also affects the cerebral vasculature as indicated by loss of blood-brain barrier (BBB) integrity. Therefore, therapeutical recanalization includes an enhanced risk for hemorrhagic transformation and blee... |
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Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency.
J. Surg. Res. 193(1) , 399-406, (2015) Both hyperinflammation during sepsis and etomidate can suppress adrenal function. In this study, we explored whether pretreatment with etomidate can relieve adrenal suppression and its impact on outcomes of cecal ligation and puncture (CLP)-induced septic rat... |
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Antitumor DNA vaccination against the Sox2 transcription factor.
Int. J. Oncol. 45(1) , 139-46, (2014) As cancer stem cells (CSCs) are resistant to chemotherapy, radiotherapy and targeted molecular therapy, immunotherapy of tumors could be aimed at their elimination. Markers specific for CSCs have not been identified to date, but microarray analyses have shown... |
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Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.
Infect. Immun. 82(11) , 4477-86, (2014) Cystic fibrosis (CF) patients have increased susceptibility to chronic lung infections by Pseudomonas aeruginosa, but the ecophysiology within the CF lung during infections is poorly understood. The aim of this study was to elucidate the in vivo growth physio... |