Methyl-β-cyclodextrin
Methyl-β-cyclodextrin structure
|
Common Name | Methyl-β-cyclodextrin | ||
|---|---|---|---|---|
| CAS Number | 128446-36-6 | Molecular Weight | 1303.303 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1206.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C54H94O35 | Melting Point | 180-182ºC | |
| MSDS | USA | Flash Point | 683.7±34.3 °C | |
|
Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
|
|
Egg drop syndrome virus enters duck embryonic fibroblast cells via clathrin-mediated endocytosis.
Virus Res. 210 , 69-76, (2015) Previous studies of egg drop syndrome virus (EDSV) is restricted to serological surveys, disease diagnostics, and complete viral genome analysis. Consequently, the infection characteristics and entry routes of EDSV are poorly understood. Therefore, we aimed t... |
|
|
Comparative study on inclusion complexation of maltosyl-beta-cyclodextrin, heptakis(2,6-di-O-methyl)-beta-cyclodextrin and beta-cyclodextrin with fucosterol in aqueous and solid state.
J. Pharm. Pharmacol. 45 , 1028, (1993) The complexation of fucosterol with three kinds of beta-cyclodextrin (beta-CyD) was investigated in aqueous solution and in the solid state. The solubility of fucosterol increased significantly on its complexation with maltosyl-beta-CyD and heptakis(2,6-di-O-... |
|
|
Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans.
J. Biol. Chem. 291 , 6912-22, (2016) The activity of Rac in leukocytes is essential for immunity. However, its role in NK cell-mediated anti-microbial signaling remains unclear. In this study, we investigated the role of Rac in NK cell mediated anti-cryptococcal killing. We found thatCryptococcu... |
|
|
Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Biochim. Biophys. Acta 1853(5) , 1022-34, (2015) Here, we demonstrate that insulin receptor (IR) tyrosine kinase catalyzes Tyr-19 and Tyr-27 phosphorylation of caveolin-2 (cav-2), leading to stimulation of signaling proteins downstream of IR, and that the catalysis is dependent on fatty acylation status of ... |
|
|
Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
PLoS ONE 6(10) , e25464, (2011) Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s). Most studies into virus entry have used cultured fibroblasts but since keratinocytes represent the p... |
|
|
An Antibody-Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies.
Clin. Cancer Res. 21 , 3252-62, (2015) Chemotherapies are limited by a narrow therapeutic index resulting in suboptimal exposure of the tumor to the drug and acquired tumor resistance. One approach to overcome this is through antibody-drug conjugates (ADC) that facilitate greater potency via targe... |
|
|
Role of the lipid rafts in the life cycle of canine coronavirus.
J. Gen. Virol. 96 , 331-7, (2015) Coronaviruses are enveloped RNA viruses that have evolved complex relationships with their host cells, and modulate their lipid composition, lipid synthesis and signalling. Lipid rafts, enriched in sphingolipids, cholesterol and associated proteins, are speci... |
|
|
Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.
PLoS ONE 6 , e19945, (2011) Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival is epithelial membrane protein-2 (EMP2), a tetraspan protein known to ass... |
|
|
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
PLoS ONE 6(10) , e26823, (2011) The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenogr... |