2-Pyrrolidinone

2-Pyrrolidinone Structure
2-Pyrrolidinone structure
Common Name 2-Pyrrolidinone
CAS Number 616-45-5 Molecular Weight 85.104
Density 1.103 Boiling Point 250 ºC
Molecular Formula C4H7NO Melting Point 25.5 ºC
MSDS Chinese USA Flash Point 138 ºC
Symbol GHS07
GHS07
Signal Word Warning

Identification of photosynthesis inhibitors of pelagic marine algae using 96-well plate microfractionation for enhanced throughput in effect-directed analysis.

Environ. Sci. Technol. 48(14) , 8003-11, (2014)

Because of large-scale production and use of an increasing diversity of chemicals in modern society, estuarine and coastal waters may be contaminated with numerous substances. Some of these compounds have the potential to affect microalgae at the base of the ...

Gellan gum-g-N-vinyl-2-pyrrolidone: synthesis, swelling, metal ion uptake and flocculation behavior.

Int. J. Biol. Macromol. 72 , 1292-300, (2014)

The synthesis of graft copolymer (gellan gum-g-N-vinyl-2-pyrrolidone) is carried out in nitrogen atmosphere using potassium bromate and silver as redox system. The reaction conditions for maximum grafting have been optimized by varying the reaction variables,...

Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention.

Pharm. Res. 32(2) , 458-68, (2015)

To develop polymeric films containing dual combinations of anti-HIV drug candidate tenofovir, maraviroc and dapivirine for vaginal application as topical microbicides.A solvent casting method was used to manufacture the films. Solid phase solubility was used ...

Determination of solubility parameters of ionic liquids and ionic liquid/solvent mixtures from intrinsic viscosity.

ChemPhysChem 15(16) , 3580-91, (2014)

The total and partial solubility parameters (dispersion, polar and hydrogen-bonding solubility parameters) of ten ionic liquids were determined. Intrinsic viscosity approaches were used that encompassed a one-dimensional method (1D-Method), and two different ...

Bioavailability, bioequivalence, and in vitro-in vivo correlation of oxybutynin transdermal patch in rabbits.

Drug Deliv Transl Res 4 , 105-15, (2015)

The first objective of the proposed research work includes comparative bioavailability and bioequivalence evaluation of oxybutynin transdermal patch with respect to different permeation enhancers. The second objective was to evaluate different in vitro method...

Ultrafine Nanoparticle-Supported Ru Nanoclusters with Ultrahigh Catalytic Activity.

Small 11 , 4385-93, (2015)

The design of an ideal heterogeneous catalyst for hydrogenation reaction is to impart the catalyst with synergetic surface sites active cooperatively toward different reaction species. Herein a new strategy is presented for the creation of such a catalyst wit...

Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state.

J. Neurosci. 34(49) , 16309-19, (2014)

The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth ho...

Only minimal regions of tomato yellow leaf curl virus (TYLCV) are required for replication, expression and movement.

Arch. Virol. 159(9) , 2263-74, (2014)

The IL-60 platform, consisting of a disarmed form of tomato yellow leaf curl virus (TYLCV) and auxiliary components, was previously developed as a nontransgenic universal vector system for gene expression and silencing that can express an entire operon in pla...

Combined use of crystalline sodium salt and polymeric precipitation inhibitors to improve pharmacokinetic profile of ibuprofen through supersaturation.

AAPS PharmSciTech 15(5) , 1334-44, (2014)

To maximize the pharmacological effect of a pain reliever such as ibuprofen, early onset of action is critical. Unfortunately, the acidic nature of ibuprofen minimizes the amount of drug that can be solubilized under gastric conditions and would be available ...

An in-vitro-in-vivo model for the transdermal delivery of cholecalciferol for the purposes of rodent management.

Int. J. Pharm. 487 , 101-9, (2015)

The natural selection of anticoagulant resistant rats has resulted in a need for an alternative to anticoagulant rodenticides which differs in both active ingredient and in the method of dosing. Cholecalciferol toxicity to rodents using the dermal route is de...