Corosolic acid
Corosolic acid structure
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Common Name | Corosolic acid | ||
|---|---|---|---|---|
| CAS Number | 4547-24-4 | Molecular Weight | 472.700 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 573.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C30H48O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 314.6±26.6 °C | |
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Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice.
PLoS ONE 10 , e0137207, (2015) To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods to p... |
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Simultaneous determination of five triterpene acids in rat plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic study after oral administration of Folium Eriobotryae effective fraction.
Biomed. Chromatogr. 29 , 1791-7, (2015) Folium Eriobotryae effective fraction (FEA), the extract of Folium Eriobotryae, had been used as anti-hyperglycemia and anti-hyperlipemia medicine in China. A previous study indicated that euscaphic acid, maslinic acid, corosolic acid, oleanolic acid and urso... |
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Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway.
PLoS ONE 10 , e0126725, (2015) Inhibition of VEGFR2 activity has been proposed as an important strategy for the clinical treatment of hepatocellular carcinoma (HCC). In this study, we identified corosolic acid (CA), which exists in the root of Actinidia chinensis, as having a significant a... |
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Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
J. Nat. Prod. 72 , 1414-8, (2009) The 3-deoxy-2-keto derivatives 5 and 7 of oleanolic acid (1) and ursolic acid (2), respectively, served as precursors to the synthesis of 35 3-deoxy derivatives of pentacyclic triterpenes. The synthesized compounds were biologically assayed for their inhibito... |
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Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
J. Med. Chem. 51 , 3540-54, (2008) Twenty-five naturally occurring pentacyclic triterpenes, 15 of which were synthesized in this study, were biologically evaluated as inhibitors of rabbit muscle glycogen phosphorylase a (GPa). From SAR studies, the presence of a sugar moiety in triterpene sapo... |
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A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.
Food Chem. 136(2) , 735-41, (2013) The occurrence of triterpene pentacyclic acids in plants is extensive, but little is known about their availability in commercial extracts. A simple GC-MS method for the simultaneous determination of betulinic, corosolic, maslinic, oleanolic and ursolic acids... |
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Plant-based corosolic acid: future anti-diabetic drug?
Biotechnol. J. 4(12) , 1704-11, (2009) Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have... |
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A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid.
Phytother Res. 26(3) , 317-24, (2012) Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. ... |
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Quantitative determination of corosolic acid in rat plasma by LC-MS/MS-ESI: application to a pharmacokinetic study.
Pak. J. Pharm. Sci. 27(3) , 511-6, (2014) A sensitive and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of corosolic acid (CRA) in rat plasma. The plasma samples were prepared by a simple protein precipitation treatment. Chro... |
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[Chemical constituents from Exochorda racemosa].
Zhongguo Zhong Yao Za Zhi 36(9) , 1198-201, (2011) To study the chemical constituents of Exochorda racemosa.Compounds were isolated and purified by silica gel, Sephadex LH-20, MCI gel and RP-18 column chromatography, and their structures were determined by spectroscopic analysis.Twenty compounds were isolated... |