Sesamin
Sesamin structure
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Common Name | Sesamin | ||
|---|---|---|---|---|
| CAS Number | 607-80-7 | Molecular Weight | 354.353 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 504.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H18O6 | Melting Point | 122-124ºC | |
| MSDS | Chinese USA | Flash Point | 212.3±30.0 °C | |
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Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.
Sci. Rep. 4 , 5896, (2014) Dysfunctions of the mitochondria and the ubiquitin-proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the order of these events remains unclear. Here, we show that ... |
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Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
Mol. Biol. Rep. 39(6) , 6867-73, (2012) Metabolic transformations of two substrates for human cytochrome P450 (CYP450) 2C9, tolbutamide and diclofenac, were investigated in hepatic microsomes from Atlantic salmon (Salmo salar L.). Tolbutamide hydroxylation followed Michaelis-Menten kinetics. Mean a... |
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Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense.
Eur. J. Nutr. 53(8) , 1659-68, (2014) Nutritional control has been proposed as a potential therapy for slowing the senescence of immune function and decreasing mortality. This study investigated whether sesamin could modify host defense systems and extend the lifespan of the nematode Caenorhabdit... |
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Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats.
J. Nutr. 143(7) , 1067-73, (2013) We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of this stu... |
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Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.
Bioorg. Med. Chem. 19 , 677-83, (2011) Five new benzenoids, benzocamphorins A-E (1-5), and 10 recently isolated triterpenoids, camphoratins A-J (16-25), together with 23 known compounds including seven benzenoids (6-12), three lignans (13-15), and 13 triterpenoids (26-38) were isolated from the fr... |
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Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.
Nutrients 6(5) , 1931-44, (2014) Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number ... |
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A phytochemical investigation of Zanthoxylum setulosum.
Nat. Prod. Commun. 6(12) , 1807-8, (2011) The crude bark extract of Zanthoxylum setulosum from Monteverde, Costa Rica was notably cytotoxic (100% kill at 100 microg/mL) to MCF-7, MDA-MB-231, and MDA-MB-468 cells in vitro. Phytochemical studies of the bark extract revealed the triterpenoid lupeol, the... |
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Sesamin synergistically potentiates the anticancer effects of γ-tocotrienol in mammary cancer cell lines.
Fitoterapia 84 , 347-59, (2013) γ-Tocotrienol and sesamin are phytochemicals that display potent anticancer activity. Since sesamin inhibits the metabolic degradation of tocotrienols, studies were conducted to determine if combined treatment with sesamin potentiates the antiproliferative ef... |
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Mechanisms mediating the synergistic anticancer effects of combined γ-tocotrienol and sesamin treatment.
Planta Med. 78(16) , 1731-9, (2012) Epidemiological studies have highlighted the ability of phytochemicals to reduce the risk of breast cancer by attenuating specific intracellular signaling pathways that regulate cell proliferation and survival. γ-Tocotrienol is a natural form of vitamin E tha... |
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Sesquiterpenes from Oplopanax horridus.
J. Nat. Prod. 73 , 563-7, (2010) From the anti-TB active fractions of the inner stem bark of Oplopanax horridus, two new heterocyclic nerolidol derivatives, 3,10-epoxy-3,7,11-trimethyldodeca-1,6-dien-11-ol, named neroplomacrol (1), and rel-(3S,6R,7S,10R)-7,10-epoxy-3,7,11-trimethyldodec-1-en... |