normorphine
normorphine structure
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Common Name | normorphine | ||
|---|---|---|---|---|
| CAS Number | 466-97-7 | Molecular Weight | 271.31100 | |
| Density | 1.48g/cm3 | Boiling Point | 485.8ºC at 760 mmHg | |
| Molecular Formula | C16H17NO3 | Melting Point | 276-277ºC | |
| MSDS | N/A | Flash Point | 247.6ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Analysis of unconjugated morphine, codeine, normorphine and morphine as glucuronides in small volumes of plasma from children.
J. Pharm. Biomed. Anal. 13(1) , 27-32, (1995) A sensitive method for the analysis of unconjugated morphine, codeine, normorphine and total morphine after hydrolysis of glucuronide conjugates is described. The method was applicable to 50-microliters volumes of plasma. The analytes were converted to heptaf... |
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Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations.
Int. J. Legal Med. 123(5) , 387-94, (2009) This work presents two cases of codeine intoxication in 3-year-old monozygotic twin brothers while treated with a codeine slow-release formulation. One child had to be admitted to the hospital, whereas the other one died at home after aspiration of gastric co... |
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Ethanol interference with morphine metabolism in isolated guinea pig hepatocytes.
Pharmacol. Toxicol. 79(3) , 114-9, (1996) It has previously been shown that guinea pig hepatocytes metabolise morphine in a fashion similar to humans. The metabolism of morphine (5 muM) and the formation of metabolites morphine-3-glucuronide, morphine-6-glucuronide and normorphine was studied in the ... |
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Serum and cerebrospinal fluid morphine pharmacokinetics after single doses of intravenous and intramuscular morphine after hip replacement surgery.
Eur. J. Clin. Pharmacol. 63(9) , 837-42, (2007) To compare the time course of morphine and metabolite concentrations in serum and cerebrospinal fluid (CSF) after intravenous and intramuscular administration after surgery.This was a randomized double-blind, double-dummy study in patients who had undergone h... |
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Partial and full agonism in endomorphin derivatives: comparison by null and operational model.
Peptides 27(6) , 1507-13, (2006) The partial mu-opioid receptor pool inactivation strategy in isolated mouse vas deferens was used to determine partial agonism of endomorphins and their analogs (endomorphin-1-ol, 2',6'-dimethyltyrosine (Dmt)-endomorphin-1, endomorphin-2-ol and (D-Met2)-endom... |
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A novel opioid structure which accepts protonated as well as non-protonated nitrogen: a family of pure, delta receptor selective antagonists.
Life Sci. 50(18) , 1371-8, (1992) Conventional opioids including opioid peptides require an "opioid" nitrogen which exists in protonated state while interacting with the receptor. In the present paper we demonstrate that the Tyr-Pro-Gly-Phe-Leu-Thr hexapeptide sequence accepts N-terminal subs... |
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Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP.
Can. J. Physiol. Pharmacol. 76(3) , 340-6, (1998) Cannabinoid receptor agonists inhibit electrically evoked isometric contractions of the myenteric plexus--longitudinal muscle preparation of the guinea-pig small intestine (MPLM), probably by reducing release of acetylcholine (ACh) through the activation of p... |
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Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens.
Neuropeptides 25(2) , 127-9, (1993) The kinetic parameters of antagonism by the delta opioid receptor selective antagonist N-t-Boc-Tyr-Pro-Gly-Phe-Leu-Thr, obtained by using moderately selective or selective agonists, were compared in the mouse vas deferens bioassay. The apparent affinity for t... |
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Simultaneous quantification of opiates and effect of pigmentation on its deposition in hair.
Arch. Pharm. Res. 33(11) , 1805-11, (2010) In forensic toxicology, the abuse of various opiate preparations, such as raw opium and heroin, is of interest since the metabolic pathways of these opiates overlap. Although the pharmaco(toxico)kinetics in hair is not clearly understood, melanin is thought t... |
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beta-Funaltrexamine, a gauge for the recognition site of wildtype and mutant H297Q mu-opioid receptors.
Synapse 49(1) , 55-60, (2003) The antagonist beta-funaltrexamine (beta-FNA), known to bind covalently to mu-opioid receptors by a two-step, doubly discriminating sequence, was used as a sensitive gauge to compare wildtype to mutant H297Q mu-opioid receptors. We addressed whether this muta... |