benzoylecgonine
benzoylecgonine structure
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Common Name | benzoylecgonine | ||
|---|---|---|---|---|
| CAS Number | 519-09-5 | Molecular Weight | 289.32600 | |
| Density | 1.29 g/cm3 | Boiling Point | 442.4ºC at 760 mmHg | |
| Molecular Formula | C16H19NO4 | Melting Point | 195ºC | |
| MSDS | USA | Flash Point | 221.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Formation of benzoylecgonine isopropyl ester following solid-phase extraction.
J. Anal. Toxicol. 36(2) , 141-3, (2012) In forensic toxicology general alkaline drug screens typically utilize liquid liquid [LLE] or solid phase extraction [SPE] sample preparation techniques. It is expected that different drugs will be detected when a laboratory changes techniques. In this study,... |
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The effects of benzoylecgonine, oxytocin, ritodrine and atosiban on the contractility of myometrium. An experimental study.
Clin. Exp. Obstet. Gynecol. 39(1) , 36-42, (2012) To investigate the response of pregnant and non pregnant rat myometrium to benzoylecgonine, a cocaine metabolite, and oxytocin and to investigate the efficiency of ritodrine and atosiban to overcome the effects of benzoylecgonine and oxytocin.Isolation of rat... |
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LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats.
Pharmacol. Rep. 64(6) , 1337-49, (2012) We employed a cocaine intravenous self-administration model based on positive reinforcement of animals' instrumental reactions (i.e., lever pressing) rewarded by a dose of the drug. We also carried out simultaneous characterization of the pharmacokinetics of ... |
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Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, drug-user populations and surface-contaminated specimens.
J. Anal. Toxicol. 36(6) , 390-8, (2012) Hair specimens were analyzed for cocaine (COC), benzoylecgonine (BE), cocaethylene (CE) and norcocaine (NCOC) by liquid chromatography-tandem mass spectrometry. Drug-free hair was contaminated in vitro with COC from different sources with varied COC analyte c... |
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Permeation and metabolism of cocaine in the nasal mucosa.
Eur. J. Drug Metab. Pharmacokinet. 37(4) , 255-62, (2012) The rapid onset of psychostimulatory effects of cocaine following intranasal administration suggests either extremely rapid absorption into the bloodstream or the potential for cocaine's access to the suggested direct nose-to-brain transport pathway. Cocaine ... |
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A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
J. Subst. Abuse Treat. 43(3) , 303-12, (2012) This is a randomized, double-blind, placebo-controlled study of modafinil treatment for cocaine dependence. Patients (N = 210) who were actively using cocaine at baseline were randomized to 8 weeks of modafinil (0 mg/day, 200 mg/day, or 400 mg/day) combined w... |
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Probing cocaine-antibody interactions in buffer and human serum.
PLoS ONE 7(7) , e40518, (2012) Despite progress in cocaine immunotherapy, the kinetic and thermodynamic properties of antibodies which bind to cocaine and its metabolites are not well understood. It is also not clear how the interactions between them differ in a complex matrix such as the ... |
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Validation of a gas chromatography-ion trap-tandem mass spectrometry assay for the simultaneous quantification of cocaine, benzoylecgonine, cocaethylene, morphine, codeine, and 6-acetylmorphine in aqueous solution, blood, and skeletal muscle tissue.
J. Anal. Toxicol. 36(1) , 1-11, (2012) A gas chromatography-ion trap-tandem mass spectrometry method was developed and validated for the simultaneous solid-phase extraction and quantification of cocaine, benzoylecgonine, cocaethylene, morphine, codeine, and 6-monoacteylmorphine in blood, muscle ti... |
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Development and validation of two LC-MS/MS methods for the detection and quantification of amphetamines, designer amphetamines, benzoylecgonine, benzodiazepines, opiates, and opioids in urine using turbulent flow chromatography.
Anal. Bioanal. Chem 405(1) , 247-58, (2013) In the context of driving ability diagnostics in Germany, administrative cutoffs for various drugs and pharmaceuticals in urine have been established. Two liquid chromatography-tandem mass spectrometry methods for simultaneous detection and quantification of ... |
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Extending the dynamic range of the ion trap by differential mobility filtration.
J. Am. Soc. Mass Spectrom. 24(9) , 1428-36, (2013) A miniature, planar, differential ion mobility spectrometer (DMS) was interfaced to an LCQ classic ion trap to conduct selective ion filtration prior to mass analysis in order to extend the dynamic range of the trap. Space charge effects are known to limit th... |