Trimethadione
Trimethadione structure
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Common Name | Trimethadione | ||
|---|---|---|---|---|
| CAS Number | 127-48-0 | Molecular Weight | 143.14100 | |
| Density | 1.171g/cm3 | Boiling Point | 78-80°C 5mm | |
| Molecular Formula | C6H9NO3 | Melting Point | 45-46°C | |
| MSDS | Chinese USA | Flash Point | 78-80°C/5mm | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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[Fetal trimethadione syndrome].
Ryōikibetsu shōkōgun shirīzu (33) , 704, (2001)
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[Fetal trimethadione effects].
Ryōikibetsu shōkōgun shirīzu (30 Pt 5) , 94-5, (2000)
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Trimethadione metabolism as a probe drug to estimate hepatic oxidizing capacity in rats.
Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. 104(2) , 205-7, (1993) 1. Trimethadione (TMO) has the properties required of probe drugs for the evaluation of hepatic oxidizing capacity in vivo. 2. TMO is demethylated to dimethadione (DMO), its only metabolite, in the liver after oral administration. 3. In rats with various type... |
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Trimethadione as a probe drug to estimate hepatic oxidizing capacity in humans.
Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 115(3) , 211-6, (1996) Trimethadione (TMO) has the properties required of probe drugs for the evaluation of hepatic drug-oxidizing capacity in humans in vivo. TMO is demethylated to dimethadione (DMO), its only metabolite, in the liver after oral administration. Involvement of two ... |
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Zebrafish (Danio rerio) embryos as a model for testing proteratogens.
Toxicology 281(1-3) , 25-36, (2011) Zebrafish embryos have been shown to be a useful model for the detection of direct acting teratogens. This communication presents a protocol for a 3-day in vitro zebrafish embryo teratogenicity assay and describes results obtained for 10 proteratogens: 2-acet... |
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The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.
Eur. J. Pharmacol. 521(1-3) , 79-85, (2005) The purpose of the present study was to explore the analgesic effects of the low voltage-activated T-type Ca2+ channel blockers ethosuximide, trimethadione, and mibefradil in persistent and acute nociceptive tests. The anticonvulsant effects of the compounds ... |
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The effects of organic solvents on trimethadione n-demethylation in rats.
Res. Commun. Mol. Pathol. Pharmacol. 104(2) , 229-39, (1999) Many organic solvents are frequently used as support solvents to dissolve chemicals in the study concerning drug metabolism mediated by cytochrome P450. However, some organic solvents used as the support solvents affect the chemical's metabolism. It has been ... |
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Trimethadione metabolism and microsomal monooxygenases in untreated and phenobarbital-treated rhesus monkeys.
Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 120(2) , 317-20, (1998) The contribution of induced cytochrome P450 (P450) isozymes (CMLa; CYP2B, CMLb; CYP2A and CMLc; CYP3A) and related enzymes to trimethadione (TMO) metabolism in phenobarbital-treated rhesus monkey were investigated. The animals received a single dose of TMO (4... |
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Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides.
Bioorg. Med. Chem. 21(4) , 841-6, (2013) The synthesis and anticonvulsant activity of novel heterocycles N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides, bioisosteres of trimethadione (TMD, oxazolidine-2,4-dione) and phenytoin (PHE), are described. TMD is an anticonvulsant drug widely used aga... |
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Effects of anticonvulsant drugs on life span.
Arch. Neurol. 63(4) , 491-6, (2006) Aging is characterized by widespread degenerative changes in tissue morphology and function and an increase in the incidence of human diseases such as cancer, stroke, and Alzheimer disease. Findings from recent genetic studies suggest that molecular mechanism... |