4-Chloro-5-sulfamoylanthranilic Acid
4-Chloro-5-sulfamoylanthranilic Acid structure
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Common Name | 4-Chloro-5-sulfamoylanthranilic Acid | ||
|---|---|---|---|---|
| CAS Number | 3086-91-7 | Molecular Weight | 250.65900 | |
| Density | 1.726g/cm3 | Boiling Point | 549.2ºC at 760mmHg | |
| Molecular Formula | C7H7ClN2O4S | Melting Point | 267°C (dec.) (lit.) | |
| MSDS | N/A | Flash Point | 286ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products.
Acta Pharmacol. Toxicol. (Copenh.) 49(3) , 223-9, (1981) Three principles for the use of HPLC with spectrophotometric detection to determine the concentration of furosemide and of 4-chloro-5-sulfamoyl anthranilic acid (CSA) were studied. A reversed phase microbondapack C18 column was used for the separation of eith... |
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The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon.
Acta Pharmacol. Toxicol. (Copenh.) 47(3) , 202-7, (1980) The percentual binding of furosemide (5 micrograms/ml) was slightly but significantly lower in serum from elderly patients than in serum from normal blood donors (96.5 +/- 0.7 versus 97.9 +/- 0.3). A significant positive correlation was demonstrated between p... |
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Furosemide accelerates gentamicin accumulation in cultured renal cells (LLC-PK1 cells).
Nephron 53(2) , 138-41, (1989) Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation in rabbit renal tissues when injected as a bolus [Kidney int. 33:3... |
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Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay.
Drug Metab. Dispos. 8(5) , 337-42, (1980) The objectives of this study were to qualitatively and quantitatively compare the metabolism, pharmacokinetics, and bioavailability of furosemide in healthy volunteers after intravenous and oral administration. We also determined the plasma protein binding of... |
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The urinary excretion of frusemide and its metabolites by kidney transplant patients.
Eur. J. Clin. Pharmacol. 32(3) , 313-5, (1987) Urine from 5 renal transplant recipients treated with frusemide was analyzed for unchanged frusemide (F), glucuronidated frusemide (G) and 4-chloro-5-sulfamoylanthranilic acid (CSA) by HPLC. In 3 recipients, whose renal function recovered steadily and whose h... |
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Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans.
Drug Metab. Dispos. 20(6) , 882-8, (1992) Furosemide (Lasix), a widely used diuretic, is metabolized by the fungus Cunninghamella elegans (ATCC 36112) to 4-chloro-5-sulfamoyl anthranilic acid (CSA), a metabolite also present in mammalian systems. This metabolite was isolated following preparative-sca... |
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Furosemide assays and disposition in healthy volunteers and renal transplant patients.
Fed. Proc. 42(6) , 1695-8, (1983) A variety of furosemide assays and their application to biological samples have been described over the past 2 decades. We describe development of a specific, sensitive assay appropriate for efficient measurement of large numbers of biological samples. With d... |
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Thin-layer chromatographic determination of furosemide and 4-chloro-5-sulfamoyl anthranilic acid in plasma and urine.
J. Chromatogr. A. 229(2) , 425-32, (1982)
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Stability-indicating proton nuclear magnetic resonance spectroscopic assay method for furosemide in tablets and injections.
J. AOAC Int. 76(3) , 526-30, (1993) A simple, specific, and accurate proton nuclear magnetic resonance (1H-NMR) spectroscopic method has been developed for the identification and assay of furosemide and its degradation product, 4-chloro-5-sulfamoylanthranilic acid (CSA), in tablets and injectio... |
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[Determination of furosemide and its metabolic products in plasma and urine by high performance liquid chromatography and clinical application].
Yakugaku Zasshi 108(11) , 1087-92, (1988)
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