m-3-g hydrate
m-3-g hydrate structure
|
Common Name | m-3-g hydrate | ||
|---|---|---|---|---|
| CAS Number | 20290-09-9 | Molecular Weight | 461.46200 | |
| Density | 1.64 g/cm3 | Boiling Point | 745.1ºCat 760 mmHg | |
| Molecular Formula | C23H27NO9 | Melting Point | 220-224°C | |
| MSDS | N/A | Flash Point | 404.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
|
Morphine glucuronidation increases its analgesic effect in guinea pigs.
Life Sci. 109(2) , 104-10, (2014) Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-administration of drugs that interfere with metabolism may affect ... |
|
|
[Rapid opiate detoxification under anesthesia (RODA)].
Rev. Med. Liege. 68(5-6) , 298-302, (2013) Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and meth... |
|
|
Determination of opiates in whole blood and vitreous humor: a study of the matrix effect and an experimental design to optimize conditions for the enzymatic hydrolysis of glucuronides.
J. Anal. Toxicol. 36(3) , 162-70, (2012) Undoubtedly, whole blood and vitreous humor have been biological samples of great importance in forensic toxicology. The determination of opiates and their metabolites has been essential for better interpretation of toxicological findings. This report describ... |
|
|
Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies.
J. Pharmacol. Exp. Ther. 349(1) , 126-37, (2014) Morphine 3-β-D-glucuronide (M3G) and morphine 6-β-D-glucuronide (M6G) are the major metabolites of morphine in humans. More recently, morphine-3-β-d-glucoside (M-3-glucoside) was identified in the urine of patients treated with morphine. Kinetic and inhibitio... |
|
|
Cardiorespiratory, gastrointestinal, and analgesic effects of morphine sulfate in conscious healthy horses.
Am. J. Vet. Res. 73(6) , 799-808, (2012) To compare the cardiorespiratory, gastrointestinal, analgesic, and behavioral effects between IV and IM administration of morphine in conscious horses with no signs of pain.6 healthy adult horses.Horses received saline (0.9% NaCl) solution (IM or IV) or morph... |
|
|
Repeated exposure to codeine alters morphine glucuronidation by affecting UGT gene expression in the rat.
Eur. J. Pharmacol. 693(1-3) , 7-14, (2012) We have previously found that phenantrenic opioids, such as heroin or naltrexone, modulate morphine glucuronidation in the rat. Here we further investigated the effects of phenantrenic opioids on morphine glucuronidation comparing the effects of codeine and h... |
|
|
Relationship between plasma concentrations of morphine and its metabolites and pain in cancer patients.
Pharm. World Sci. 32(6) , 737-43, (2010) This study was undertaken to investigate the relationship between the plasma concentration of morphine, morphine-3-glucuronide and morphine-6-glucuronide and pain in cancer patients receiving oral morphine.The trough value of plasma concentrations of morphine... |
|
|
Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children.
Clin. Pharmacokinet. 50(1) , 51-63, (2011) Model validation procedures are crucial when models are to be used to develop new dosing algorithms. In this study, the predictive performance of a previously published paediatric population pharmacokinetic model for morphine and its metabolites in children y... |
|
|
Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models.
Pharm. Res. 28(4) , 797-811, (2011) A framework for the evaluation of paediatric population models is proposed and applied to two different paediatric population pharmacokinetic models for morphine. One covariate model was based on a systematic covariate analysis, the other on fixed allometric ... |
|
|
Mapping of endogenous morphine-like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells.
J. Comp. Neurol. 519(12) , 2390-416, (2011) Endogenous morphine, morphine-6-glucuronide, and codeine, which are structurally identical to vegetal alkaloids, can be synthesized by mammalian cells from dopamine. However, the role of brain endogenous morphine and its derivative compounds is a matter of de... |